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MMP1 — RLN2

Text-mined interactions from Literome

Naqvi et al., Arthritis Res Ther 2005 : Previously, we showed that relaxin dose-dependently induces matrix metalloproteinase ( MMP ) expression in isolated joint fibrocartilaginous cells
Goldsmith et al., Ann N Y Acad Sci 2005 : In addition, relaxin negatively regulates expression of endometrial matrix metalloproteinases ( MMP ) , causing decreased endometrial levels of MMP-1 and MMP-3 proteins and increased protein levels of their endogenous inhibitor, tissue inhibitor of metalloproteinase 1 ... The negative effects of relaxin on MMP expression in the endometrium are in distinct contrast to the positive regulation of MMPs previously shown in fibroblasts from other tissues including the cervix
Weiss et al., Ann N Y Acad Sci 2005 (Premature Birth) : In an in vitro model of late human pregnancy cervix, relaxin increases MMP-1 and MMP-3 and decreases TIMP-1 levels, thus acting as a positive regulator of matrix metalloproteinases
Silvertown et al., Endocrinology 2006 (Lung Diseases) : Taken together, this study provides proof-of- principle that relaxin gene expression targeted to the mouse lungs can result in enhanced MMP activity offering potential for alleviating disease conditions characterized by dysregulation of extracellular matrix protein accumulation
Henneman et al., Arch Oral Biol 2008 : Previous studies have indicated that MMP production can be stimulated by the hormone relaxin
Kapila et al., Orthod Craniofac Res 2009 : Induction of MMP-1 ( collagenase-1 ) by relaxin in fibrocartilaginous cells requires both the AP-1 and PEA-3 promoter sites ... Using wild type or mutated minimal AP-1 and PEA-3 promoters we found that both these promoter sites are essential for the induction of MMP-1 by relaxin ... CONCLUSION - These studies show that both the AP-1 and PEA-3 promoter sites are necessary for the induction of MMP-1 by relaxin in fibrocartilaginous cells
Takano et al., Orthod Craniofac Res 2009 (Recurrence) : In the present study, we investigated the effects of relaxin on the expression of collagen type I ( Col-I ) and matrix metalloproteinase 1 (MMP-1) in stretched hPDL cells in vitro