Moe et al., Kidney Int 2000
(Amyloidosis...) :
beta2m and AGE-beta2m at 10 and 25 microg/mL induced the release of MMP-1 from human osteoarthritic synovial fibroblasts at 24 hours
Nah et al., FEBS Lett 2007
(Osteoarthritis) :
The stimulatory effect of AGE-BSA on MMP-1 , -3, and -13 were reversed by treatment with specific JNK, p38 inhibitors, suggesting JNK and p38 are involved in AGE-BSA induced MMPs and TNF-alpha
Huang et al., Rheumatology (Oxford) 2011
(Osteoarthritis) :
AGE enhanced expression and enzyme activity of MMP and ADAMTS genes and resulted in reduction of collagen II