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CTGF — MMP1

Text-mined interactions from Literome

Daniels et al., Am J Pathol 2003 (Cicatrix) : During contraction fibroblasts produced similar levels of matrix metalloproteinases ( MMPs ) -2 and -9 with TGF-beta(1) or CTGF and a modest increase in MMP-1 with CTGF only ( indicated by zymography and enzyme linked immunosorbent assay )
Bogatkevich et al., Arthritis Rheum 2007 (MAP Kinase Signaling System...) : Inhibition of MMP activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity, but significantly restored HGF inhibited collagen and CTGF accumulation
Nguyen et al., J Am Soc Nephrol 2008 (Diabetes Mellitus, Experimental...) : In conclusion, upregulation of CTGF inhibits BMP-7 signal transduction in the diabetic kidney and contributes to altered gene transcription, reduced MMP activity, glomerular basement membrane thickening, and albuminuria, all of which are hallmarks of diabetic nephropathy
Droppelmann et al., J Biol Chem 2009 : CTGF increased fibronectin ( FN ) amount, MMP-2 mRNA expression, and gelatinase activity in 3T3 cells
Wang et al., Arch Oral Biol 2012 (Neovascularization, Pathologic...) : Compared to their age matched controls, the protein levels of VEGF and CTGF were higher in 20-week experimental group, and the protein and mRNA levels of CTGF, MMP-9 , and CHM-I increased in the 24-week experimental group ( all P < 0.05 )
Zhu et al., International journal of ophthalmology 2013 : Preincubation of ARPE-19 with Y27632 ( 10mmol/L ) significantly prevented CTGF or TGF- ß induced fibronectin ( P=0.005, P=0.003 respectively ), MMP-2 ( P= 0.003, P=0.002 ), COL1A1 ( P=0.006, P=0.003 ), and COL1A2 ( P=0.006, P=0.004 ) gene expression, but not laminin ( P=0.375, P=0.516 )
Wang et al., Mol Med Report 2013 : CTGF stimulation resulted in the significant production of IL-6, IL-8, C-C motif ligand 2 (CCL2), CCL20 , MMP-1 and MMP-3 in FLSs in the presence, but not in the absence, of IL-1ß