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IL2 — TYK2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Subramaniam et al., Biochem Biophys Res Commun 1999
:
Immunoprecipitation with specific antibodies followed by Western blot analysis with antiphosphotyrosine antibody has shown that in U937 cells,
interleukin-17 induces time dependent stimulation of tyrosine phosphorylation of JAK 1, 2 and 3,
Tyk 2 and STAT 1, 2, 3 and 4 within 0.5 to 30 min. Interleukin-17 mediated tyrosine phosphorylation of these proteins strongly suggests that the JAK/STAT signaling pathway may play a major role in transducing signals from interleukin-17 receptors to the nucleus
Bacon et al., J Exp Med 1995
:
IL-12, but not
IL-2 ,
stimulates the tyrosine phosphorylation of
TYK2 and JAK2, whereas JAK1 and JAK3, which are phosphorylated in response to IL-2, are not phosphorylated after IL-12 treatment
Beadling et al., EMBO J 1994
:
An
IL-2 induced increase in JAK1 and JAK3, but not JAK2 or
Tyk2 , tyrosine phosphorylation was observed
Yu et al., J Immunol 1996
:
Finally,
IL-2 induced tyrosine phosphorylation of JAK1 and JAK3, while IL-12 induced phosphorylation of JAK2 and
TYK2 in both preactivated primary NK and NK3.3 cells