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GRB10 — RAF1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
RAF1
—
GRB10
(colocalization, biochemical)
Nantel et al., J Biol Chem 1999*
-
IRef Biogrid Interaction:
RAF1
—
GRB10
(direct interaction, two hybrid)
Nantel et al., J Biol Chem 1999*
-
IRef Biogrid Interaction:
RAF1
—
GRB10
(physical association, affinity chromatography technology)
Nantel et al., J Biol Chem 1999*
-
IRef Biogrid Interaction:
RAF1
—
GRB10
(direct interaction, pull down)
Nantel et al., J Biol Chem 1998*
-
IRef Biogrid Interaction:
RAF1
—
GRB10
(direct interaction, two hybrid)
Nantel et al., J Biol Chem 1998*
-
IRef Biogrid Interaction:
RAF1
—
GRB10
(physical association, affinity chromatography technology)
Nantel et al., J Biol Chem 1998*
-
IRef Hprd Interaction:
RAF1
—
GRB10
(in vivo)
Nantel et al., J Biol Chem 1999*, Nantel et al., J Biol Chem 1998*
-
IRef Hprd Interaction:
RAF1
—
GRB10
(two hybrid)
Nantel et al., J Biol Chem 1999*, Nantel et al., J Biol Chem 1998*
-
IRef Hprd Interaction:
RAF1
—
GRB10
(in vitro)
Nantel et al., J Biol Chem 1999*, Nantel et al., J Biol Chem 1998*
-
IRef Ophid Interaction:
RAF1
—
GRB10
(aggregation, confirmational text mining)
Nantel et al., J Biol Chem 1999*
-
IRef Ophid Interaction:
RAF1
—
GRB10
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Nantel et al., J Biol Chem 1999
:
Thus, we infer that
Grb10 may
regulate signaling between plasma membrane receptors and the apoptosis inducing machinery on the mitochondrial outer membrane by modulating the anti-apoptotic activity of mitochondrial
Raf-1
Kebache et al., J Biol Chem 2007
(Adenocarcinoma...) :
Because total
Raf-1 , ERK, and Akt kinase activities are not
impaired in the absence of
Grb10 , we propose that this adapter protein creates a subpopulation of Raf-1 with specific anti-apoptotic activity