Michael et al., Mol Cell Biol 2000
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Rather, HDAC inhibitors augment CREB activity during the late attenuation phase by prolonging CREB phosphorylation on chromosomal but, remarkably, not on extrachromosomal templates
Canettieri et al., Nat Struct Biol 2003
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Here we show that HDAC1 associates with and blocks Ser133 phosphorylation of CREB during pre-stimulus and attenuation phases of the cAMP response
Lu et al., J Biol Chem 2003
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Although inhibition of histone deacetylase activity results in an increase of CREB- or CBP mediated gene expression, mutation of all three putative acetylation sites in the CREB activation domain markedly enhances the ability of CREB to activate a cAMP-responsive element dependent reporter gene