Gene interactions and pathways from curated databases and text-mining

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DDX58 — TNF

Text-mined interactions from Literome

Matikainen et al., J Virol 2006 : IFN-alpha and TNF-alpha induced the expression of the RIG-I , TLR3, MyD88, TRIF, and IRF7 genes, whereas no detectable TLR7 and TLR8 was seen in A549 cells
Kitamura et al., J Dermatol Sci 2007 (Psoriasis) : The present study was designed to investigate the effects of interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha on RIG-I expression in human keratinocytes, and the expression of RIG-I in skin lesions of psoriasis vulgaris, in which IFN-gamma and TNF-alpha are considered to be involved in its pathogenesis
Matsumiya et al., J Immunol 2007 (Uterine Cervical Neoplasms) : Our findings support a sequential mechanism whereby TNF-alpha leads to stabilization of IFN-epsilon mRNA, increased IFN-epsilon synthesis, engagement of type I IFNRs, increased STAT1 expression and phosphorylation, and up-regulation of RIG-I expression
Wang et al., J Immunol 2008 (Salmonella Infections, Animal) : Interference of RIG-I expression short interfering RNA represses the expression of LPS induced TNF-alpha, whereas over-expression of RIG-I leads to the activation of TNF-alpha promoter and the induction of TNF-alpha expression ... Thus, RIG-I plays a key role in the expression of TNF-alpha in macrophages in response to LPS stimulation, mainly for the late phase LPS induced expression of TNF-alpha
Imaizumi et al., Immunol Lett 2009 (Arthritis, Rheumatoid) : RNA interference against interferon (IFN)-beta abolished the TNF-alpha induced RIG-I expression
Kawaguchi et al., Immunol Lett 2009 (Colonic Neoplasms) : RIG-I was constitutively expressed in the epithelial cell lines HT-29, and IFN-gamma and TNF-alpha enhanced the RIG-I expression in a dose dependent manner