Li et al., Circulation 2000
:
Oxidized LDL upregulates angiotensin II type 1 receptor expression in cultured human coronary artery endothelial cells : the potential role of transcription factor NF-kappaB ... Pretreatment of cells with CAPE inhibited ox-LDL mediated degradation of IkappaBalpha and NF-kappaB activation and inhibited ox-LDL induced upregulation of AT1R expression ... These observations suggest an important role of ox-LDL mediated AT1R upregulation in cell injury
Keidar et al., J Renin Angiotensin Aldosterone Syst 2002
:
In contrast, native LDL or acetylated LDL did not significantly affect macrophage AT(1)-receptor mRNA expression
Strawn et al., Atherosclerosis 2008
(Hypercholesterolemia) :
Our data provide support for a positive regulatory role of plasma LDL on AT(1) receptor mediated HSC differentiation and the production of pro-atherogenic monocytes
Nickenig et al., Eur J Med Res 1997
(Hypercholesterolemia) :
LDL causes in cultured vascular smooth muscle cells an up-regulation of AT1 receptor gene expression which is followed by an enhanced functional response upon stimulation with angiotensin II
Nickenig et al., J Hypertens Suppl 1997
:
To investigate the effect of oxidized low-density lipoprotein (LDL) on angiotensin type 1 (AT1) receptor expression and on angiotensin induced mitogenesis in vascular smooth muscle cells ... Recent studies have demonstrated that native LDL profoundly increases the AT1 receptor gene expression in vascular smooth muscle cells