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PIK3CA — PIK3CD
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Webb et al., J Immunol 2005
:
This work demonstrates that
PI3K activity is critical for T cell development and
depends on the combined function of p110gamma and
p110delta
Papakonstanti et al., EMBO J 2007
:
This work identifies the RhoA/ROCK pathway as a major target of
p110delta mediated
PI3K signalling, and establishes for the first time that PI3K controls itself, via a feedback loop involving PTEN
Garçon et al., Blood 2008
:
Using a quantitative imaging based assay, we show that the
PI3K activity at the T cell-APC contact area is
dependent on the
p110delta , but not the p110gamma, isoform of PI3K
Billottet et al., Cancer Res 2009
(Leukemia, Promyelocytic, Acute) :
In summary, class I
PI3K signaling,
mediated by p110beta and
p110delta , plays an important role in basal and ATRA induced cell survival mechanisms in APL
Janas et al., J Exp Med 2010
:
Here, we show that
PI3K signaling from the preTCR
requires p110delta , but not p110gamma
Jiang et al., J Biol Chem 2010
(Prostatic Neoplasms) :
Basal
PI3K activity was
mediated by p110beta in PC3 cells and by both p110beta and
p110delta in LNCaP cells, whereas p110alpha was required for PI3K activation in response to RTK stimulation by heregulin-beta1 ... These findings show that basal
PI3K activity in PTEN-deficient PCa cells is RTK independent and can be
mediated by p110beta and
p110delta