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FAS — RIPK1

Pathways - manually collected, often from reviews:

• NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha: TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD) → FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD) (modification, activates)
  Micheau et al., Cell 2003, Yang et al., Cell 1997, Saitoh et al., EMBO J 1998, Chang et al., Science 1998
• NCI Pathway Database FAS (CD95) signaling pathway: FADD (FADD) → FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) (modification, collaborate)
  Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: cIAP1-2 (BIRC2/BIRC3) → FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) (modification, inhibits)
  Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) → RIP (RIPK1) (modification, collaborate) Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) → FASLG/FAS (trimer) complex (FAS-FASLG) (modification, collaborate)
  Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: RIP (RIPK1) → FASLG/FAS (trimer) complex (FAS-FASLG) (modification, collaborate)
  Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FADD (FADD) → FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) (modification, collaborate)
  Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: c-FLIP (CFLAR) → FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) (modification, inhibits)
  Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) → RIP (RIPK1) (modification, collaborate) Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) → FASLG/FAS (trimer) complex (FAS-FASLG) (modification, collaborate)
  Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: RIP (RIPK1) → FASLG/FAS (trimer) complex (FAS-FASLG) (modification, collaborate)
  Holler et al., Nat Immunol 2000, Geserick et al., J Cell Biol 2009, Stanger et al., Cell 1995, Kischkel et al., EMBO J 1995
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FAS (CD95) signaling pathway: FASLG/FAS (trimer)/FADD/FADD/RIP complex (FAS-FASLG-FADD-RIPK1) → IKK complex complex (CHUK-IKBKB-IKBKG) (modification, activates)
  Kreuz et al., J Cell Biol 2004
  Evidence: mutant phenotype, assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: RIPK1 — FAS (direct interaction, two hybrid) Stanger et al., Cell 1995
• IRef Hprd Interaction: RIPK1 — FAS (in vitro) Stanger et al., Cell 1995, Juo et al., Curr Biol 1998
• IRef Hprd Interaction: RIPK1 — FAS (two hybrid) Stanger et al., Cell 1995, Juo et al., Curr Biol 1998
• IRef Intact Interaction: RIPK1 — FAS (physical association, two hybrid) Stanger et al., Cell 1995
• IRef Ophid Interaction: RIPK1 — FAS (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Morgan et al., J Immunol 2009 : In this study, we show that in Jurkat T lymphocytes, RIP1 is also necessary for the most efficient activation of downstream caspases by Fas when treated with membrane bound Fas ligand, but not with agonistic Abs or cross linked soluble Fas ligand
Geserick et al., J Cell Biol 2009 : These results demonstrate a fundamental role for RIP1 in CD95 signaling and provide support for a physiological role of caspase independent death receptor mediated cell death