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PDX1 — PPARA
Text-mined interactions from Literome
Sun et al., Endocrinology 2008
(Insulinoma...) :
In the present study, we tested the hypothesis that
PPARalpha regulates the expression of
PDX-1 in beta-cells ... Treatment with MK886 inhibited expression of PPARalpha, blocking
PPARalpha regulated
PDX-1 expression, and the downstream transcription events of PDX-1
Guo et al., Acta Pharmacol Sin 2010
(Insulinoma) :
To investigate whether AMP activated protein kinase (AMPK) regulates the expression of
pancreatic duodenal homeobox-1 (PDX-1) , a beta-cell-specific transcription factor and whether
PPARalpha/gamma is
involved in the regulation of pancreatic beta-cell lines after acute stimulation ... AMPK regulates the expression of
PDX-1 at both the transcriptional and protein levels, and
PPARalpha may be acutely
involved in the regulation of INS-1 cells
Zhu et al., PloS one 2013
:
We further show that activation of
PPAR? could
restore GS-induced reduction of
Pdx1 and Mafa protein levels, leading to improved insulin secretion and synthesis