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LEP — VEGFA

Text-mined interactions from Literome

Yamagishi et al., Microvasc Res 2003 (Eye Diseases...) : An anti-oxidant, N-acetylcysteine, or PEDF completely prevented the leptin induced upregulation of vascular endothelial growth factor ( VEGF ) mRNA levels as well as any increase in DNA synthesis in microvascular EC
Islami et al., Mol Hum Reprod 2003 : Thus, we hypothesized that products of cytotrophoblastic cells may play a role in placental angiogenesis and we therefore investigated the effects of leptin and hCG on cytotrophoblast VEGF secretion
Suganami et al., Diabetes 2004 (Diabetic Retinopathy...) : This effect was thought to be mediated at least partly through the activation of signal transducers and activators of transcription ( STAT ) 3, because adenoviral transfection of the dominant negative form of STAT3 abolished the leptin induced upregulation of VEGF mRNA expression in retinal endothelial cells
Ramos et al., Endocrinology 2005 : Disruption of leptin signaling resulted in a significant reduction of IL-1 receptor type I, leukemia inhibitory factor, vascular endothelial growth factor receptor 2, and beta3-integrin levels
Frankenberry et al., Am J Surg 2004 (Neovascularization, Pathologic...) : Leptin significantly induced expression of vascular endothelial growth factor ( VEGF ), transforming growth factor-beta1 ( TGF-beta1 ), and basic fibroblast growth factor (bFGF) in DU145 and PC-3 cells
Misztal-Dethloff et al., Endocr Regul 2004 : Effect of leptin on proliferative activity and vascular endothelial growth factor ( VEGF ) secretion from cultured endothelial cells HECa10 in vitro ... Murine leptin in concentrations from 5 to 25 ng/ml stimulated the proliferative activity of 72 h endothelial cell cultures and in concentrations from 0.5 to 25 ng/ml augmented the release of VEGF into supernatants of 24 h and 72 h cultured cells ... Leptin stimulated proliferation and VEGF secretion of endothelial cells in vitro
Aleffi et al., Hepatology 2005 (Liver Cirrhosis) : Leptin also increased gene expression of the proangiogenic cytokines vascular endothelial growth factor ( VEGF ) and angiopoietin-1, and VEGF was also upregulated at the protein level
Styer et al., Endocrinology 2008 (Disease Models, Animal...) : Findings of this study show that the disruption of leptin signaling by ip injection of the pegylated leptin peptide receptor antagonist ( LPrA ) impairs the establishment of endometriosis-like lesions ( derived from uteri of C57BL/6 female siblings ) and results in a reduction of viable organized glandular epithelium, vascular endothelial growth factor-A expression, and mitotic activity
Carino et al., Int J Cancer 2008 (Adenocarcinoma...) : Here, we report that in benign ( primary and HES ) and cancerous-endometrial epithelial cells (EEC) ( An3Ca, SK-UT2 and Ishikawa ), leptin in a dose dependent manner regulates vascular endothelial growth factor , ( VEGF ) ; interleukin-1 beta, ( IL-1beta); leukemia inhibitory factor, ( LIF ) and their respective receptors, VEGFR2, IL-1R tI and LIFR ... Remarkably, leptin induces a greater increase in VEGF/VEGFR2 and LIF levels in cancer than in benign cells
Shin et al., Yonsei Med J 2008 (Obesity) : We investigated whether human airway smooth muscle ( ASM ) cells express adiponectin receptors and whether adiponectin and leptin regulate human ASM cell proliferation and vascular endothelial growth factor ( VEGF ) release ... Leptin promoted VEGF release by human ASM cells, while adiponectin did not influence VEGF release ... However, adiponectin did not regulate human ASM cell proliferation or VEGF release, while leptin stimulated VEGF release by human ASM cells
Birmingham et al., Carcinogenesis 2009 (Colonic Neoplasms...) : Leptin treatment induced dose dependent increases in VEGF only in IMCE cells
Rene Gonzalez et al., Breast Cancer Res 2009 (Breast Neoplasms...) : Mouse tumor stroma in ER+ BC expressed high levels of VEGF and leptin that was induced by leptin signaling
Gonzalez-Perez et al., Cell Signal 2010 (Mammary Neoplasms, Experimental) : Leptin upregulates VEGF in breast cancer via canonic and non-canonical signalling pathways and NFkappaB/HIF-1alpha activation ... Leptin signalling upregulates VEGF in human and mouse mammary tumor cells ( MT ), but the specific molecular mechanisms are largely unknown ... A series of VEGF-promoter Luc-reporters ( full-length and transcription factor binding deletions ) were transfected into MT to analyze leptin regulation of VEGF transcription ... Deletion analysis of VEGF promoter and RNA knockdown shows that HIF-1alpha and NFkappaB are essentials for leptin regulation of VEGF ... SP1 was involved in leptin regulation of VEGF in 4T1 cells ... AP1 was not involved and AP2 repressed leptin induced increase of VEGF ... Overall, these data suggest that leptin signalling regulates VEGF mainly through HIF-1alpha and NFkappaB ... These results delineate a comprehensive mechanism for leptin regulation of VEGF in MT. Disruption of leptin signalling could be used as a novel way to treat breast cancer
Aleffi et al., Am J Physiol Gastrointest Liver Physiol 2011 (Neovascularization, Pathologic) : Both leptin and PDGF increased the expression of HIF-1a and VEGF in HSC ... In the presence of rapamycin, a specific mTOR inhibitor, leptin and PDGF were no longer able to activate mTOR, and expression of VEGF was reduced , whereas HIF-1a abundance was not affected
Guo et al., PloS one 2011 (Mammary Neoplasms, Animal) : Notch, IL-1 and leptin crosstalk outcome ( NILCO ) is critical for leptin induced proliferation, migration and VEGF/VEGFR-2 expression in breast cancer ... We have previously reported that leptin induces the growth of breast cancer and the expression of VEGF/VEGFR-2 and IL-1 system ... To test this hypothesis, leptin 's effects on the expression and activation of Notch signaling pathway and VEGF/VEGFR-2/IL-1 were determined in mouse ( 4T1, EMT6 and MMT ) breast cancer cells ... In addition, blockade of IL-1R tI inhibited leptin induced Notch, Hey2 and survivin as well as VEGF/VEGFR-2 expression ... These data suggest leptin is an inducer of Notch ( expression/activation ) and IL-1 signaling modulates leptin effects on Notch and VEGF/VEGFR-2