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CRH — FASLG

Text-mined interactions from Literome

Dermitzaki et al., J Biol Chem 2002 : Corticotropin releasing hormone induces Fas ligand production and apoptosis in PC12 cells via activation of p38 mitogen activated protein kinase ... CRH induced Fas ligand production and apoptosis ... These effects were mediated by the CRH type 1 receptor because its antagonist antalarmin blocked CRH induced apoptosis and Fas ligand expression ... CRH activated p38 mitogen activated protein kinase, which was found to be essential for CRH induced apoptosis and Fas ligand production ... CRH also promoted a rapid and transient activation of ERK1/2, which, however, was not necessary for either CRH induced apoptosis or Fas ligand production ... Thus, CRH promotes PC12 apoptosis via the CRH type 1 receptor, which induces Fas ligand production via activation of p38
Makrigiannakis et al., Biochem Pharmacol 2003 : CRH induces the expression of apoptotic Fas ligand (FasL) on invasive extravillous trophoblast and maternal decidual cells at the fetal-maternal interface ... Furthermore, CRH increases the apoptosis of activated T lymphocytes through FasL induction, participating in the processes of both implantation and early pregnancy tolerance
Mastorakos et al., Ann N Y Acad Sci 2003 (Puerperal Disorders) : It has been suggested that CRH of fetal and maternal origin regulates FasL production, thus affecting the invasion ( implantation ) process through a local auto-paracrine regulatory loop involving the cytotrophoblast cells
Makrigiannakis et al., Curr Drug Targets Immune Endocr Metabol Disord 2004 : Furthermore, CRH increases apoptosis of activated T lymphocytes through FasL induction participating in the process of implantation and early pregnancy
Wang et al., Neurosci Lett 2004 : In the presence of CRH , OGD induced Fas-L expression was significantly increased ... The effect of CRH on Fas-L expression was inhibited by specific inhibitors of the extracellular signal regulated protein kinase ( PD98059 ) and p38 mitogen activated protein kinase ( SB203580 )
Dermitzaki et al., Biochem Biophys Res Commun 2005 : ( e ) Blockade of conventional PKC phosphorylation inhibited CRH induced calcium ion mobilization from intracellular stores as well as the CRH induced apoptosis and Fas ligand production
Minas et al., Br J Cancer 2007 (Ovarian Neoplasms) : Finally, CRH increased the expression of FasL in OvCa3 and A2780 cells through CRHR1 thereby potentiated their ability to induce apoptosis of activated peripheral blood lymphocytes
Petsas et al., Mol Hum Reprod 2012 (Pre-Eclampsia) : In vitro studies on the effect of CRH on human macrophages suggested that CRH induced the expression of the FasL protein in human macrophages and potentiated their ability to induce the apoptosis of a Fas expressing EVT based hybridoma cell line in co-cultures
Taliouri et al., Tumour Biol 2013 (Uterine Cervical Neoplasms) : It was additionally shown that CRH could induce Fas ligand (FasL) expression in ovarian carcinoma cell lines ... We further studied whether CRH could regulate FasL expression ... The current results indicated that in HeLa cells, CRH can significantly induce both FasL transcription and FasL translation