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CNTN2 — IL13

Text-mined interactions from Literome

Wäldele et al., J Virol 2004 (Cell Transformation, Viral...) : Here we show that the expression of interleukin-13 (IL-13) is upregulated as a consequence of Tax in HTLV-1 transformed T cells and ATL derived cultures
Silbermann et al., J Gen Virol 2008 (HTLV-I Infections) : Stimulation of interleukin-13 expression by human T-cell leukemia virus type 1 oncoprotein Tax via a dually active promoter element responsive to NF-kappaB and NFAT ... In HTLV transformed cells, Tax upregulates interleukin (IL)-13 , a cytokine with proliferative and anti-apoptotic functions that is linked to leukaemogenesis ... Tax stimulated IL-13 is thought to result in autocrine stimulation of HTLV infected cells and thus may be relevant to their growth ... The causal transactivation of the IL-13 promoter by Tax is predominantly dependent on a nuclear factor of activated T cells ( NFAT ) -binding P element ... Here, it was shown that the isolated IL-13 Tax-responsive element ( IL13TaxRE ) was sufficient to mediate IL-13 transactivation by Tax and NFAT1 ... However, cyclosporin A, a specific NFAT inhibitor, revealed that Tax transactivation of IL13TaxRE or wild-type IL-13 promoter was independent of NFAT and that NFAT did not contribute to IL-13 upregulation in HTLV transformed cells ... Together, these results indicate that Tax causes IL-13 upregulation in HTLV-1 infected cells via NF-kappaB