Gene interactions and pathways from curated databases and text-mining

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IL4 — TP53

Text-mined interactions from Literome

Pokrovskaja et al., J Gen Virol 1999 : Similarly, B cell activation by CD40L and IL-4 induced p53 expression without any adverse effect on cell cycle progression
Pesch et al., J Interferon Cytokine Res 1996 (Leukemia-Lymphoma, Adult T-Cell...) : Repression of interleukin-2 and interleukin-4 promoters by tumor suppressor protein p53 ... Murine wt p53 derived from pSG5p53cD strongly repressed the IL-2 and IL-4 promoters in both cell lines induced by the phorbol ester TPA and the Ca2+ ionophore ionomycin but not, however, in uninduced cells