Gene interactions and pathways from curated databases and text-mining

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CDH1 — HDAC6

Text-mined interactions from Literome

Kakihana et al., J Thorac Oncol 2009 (Carcinoma, Non-Small-Cell Lung...) : Induction of E-cadherin in lung cancer and interaction with growth suppression by histone deacetylase inhibition
Suda et al., J Thorac Oncol 2011 (Adenocarcinoma...) : We also found that the histone deacetylase inhibitor, MS-275, restored E-cadherin expression and moderate sensitivity to erlotinib in HCC4006ER cells, on the other hand, transforming growth factor beta, an inducer of EMT, led to moderate erlotinib resistance in HCC4006 parental cells
Yuan et al., Zhonghua Zhong Liu Za Zhi 2012 (Carcinoma, Squamous Cell...) : Additionally, the downregulation of HDAC6 protein expression markedly decreased the expressions of cyclin D1, cyclin E, cdk2 and MMP-9 proteins, but increased the expressions of p21 and E-cadherin proteins