Gene interactions and pathways from curated databases and text-mining

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TNP1 — TP53

Text-mined interactions from Literome

Yeh et al., Proc Natl Acad Sci U S A 2000 (Corneal Neovascularization) : The antiangiogenic agent TNP-470 requires p53 and p21CIP/WAF for endothelial cell growth arrest ... We conclude that TNP-470 induces p53 activation through a unique mechanism in endothelial cells leading to p21 ( CIP/WAF ) expression and subsequent growth arrest
Lien et al., Biochem Pharmacol 2004 : We have found that TNP-470 did not only induce p53 and p21 ( Cip1 ) but also cyclin D1 in the basic fibroblast growth factors (bFGF) treated endothelial cells