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SOCS1 — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wan et al., EMBO Rep 2002
:
Jab1 was initially identified as a co-activator of c-Jun, and it also
induces degradation of cell cycle inhibitor p27 and
tumor suppressor p53
Oh et al., J Biol Chem 2006
:
Jab1 induces the cytoplasmic localization and degradation of
p53 in coordination with Hdm2 ... Moreover,
Jab1 did not
affect the cellular localization or protein levels of
p53 in p53 and Hdm2 double-null mouse embryo fibroblasts ... Under stressed conditions, which could sequester Hdm2 in its inactive state,
Jab1 did not
affect p53
Lungu et al., J Neurovirol 2008
(Leukemia, Experimental...) :
The authors suggest that a decrease
Jab1 expression in ts1 infection
leads to accumulation of
p53 , which binds to HIF-1alpha to accelerate its degradation
Calabrese et al., Mol Cell 2009
:
We report that
SOCS1 is
required for transcriptional activity, DNA binding, and serine 15 phosphorylation of
p53 in the context of STAT5 signaling
Mallette et al., Aging 2010
(Cell Transformation, Neoplastic) :
Furthermore,
SOCS1 contributes to
p53 activation and phosphorylation on serine 15 by forming a ternary complex with ATM or ATR ... The
involvement of
SOCS1 in
p53 activation and the DNA damage response defines a novel tumor suppressor pathway and intervention point for future cancer therapeutics
Yang et al., J Cell Physiol 2011
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Jab1 , a co-activator of AP-1 transcription factor and the fifth subunit of the COP9 signalosome,
mediates degradation of the
tumor suppressor p53 and p27 ( Kip1 ) and functions as a tumor promoter in different types of human cancer