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RPL5 — TP53

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: TP53 → RPL5 (increases, RPL5 Activity, TP53 Activity) Dai et al., J Biol Chem 2004
  Evidence: Here we have shown that L5 also activates p53. Consequently, L5 enhanced p53 transcriptional activity and induced p53-dependent G1 cell cycle arrest.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: RPL5 — TP53 (physical association, affinity chromatography technology) Bursać et al., Proc Natl Acad Sci U S A 2012
• IRef Biogrid Interaction: RPL5 — TP53 (physical association, affinity chromatography technology) Dai et al., J Biol Chem 2004
• IRef Hprd Interaction: Complex of RPL5-TP53-MDM2-RPL5-TP53-TP53-MDM2-RPL5-MDM2 (in vivo) Marechal et al., Mol Cell Biol 1994*
• IRef Intact Interaction: Complex of 244 proteins (association, pull down) Komarova et al., Mol Cell Proteomics 2011
• IRef Intact Interaction: Complex of 50 proteins (association, anti tag coimmunoprecipitation) Coffill et al., EMBO Rep 2012
• IRef Ophid Interaction: TP53 — RPL5 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Lindström et al., PloS one 2010 (Brain Neoplasms...) : In these settings, RPL11 was critical for maintaining p53 protein stability but was not strictly required for p53 protein synthesis
Sun et al., J Biol Chem 2010 : Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11 dependent p53 activation
Golomb et al., Mol Cell 2012 : Furthermore, p53 activation is dependent on RPL5 and RPL11