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MSH2 — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MSH2 — TP53 (physical association, affinity chromatography technology) Zink et al., Oncogene 2002*
• IRef Biogrid Interaction: MSH2 — TP53 (physical association, affinity chromatography technology) Yang et al., Oncogene 2004*
• MIPS CORUM MSH2/6-BLM-p53-RAD51 complex: MSH2/6-BLM-p53-RAD51 complex complex (BLM-MSH2-MSH6-RAD51-TP53) Yang et al., Oncogene 2004*
• IRef Corum Interaction: Complex of 11 proteins (association, anti bait coimmunoprecipitation) Yang et al., Oncogene 2004*
• IRef Hprd Interaction: Complex of 17 proteins (in vivo) Yang et al., Oncogene 2004*

Text-mined interactions from Literome

Koshiji et al., Mol Cell 2005 (Chromosomal Instability...) : HIF-1alpha displaces the transcriptional activator Myc from Sp1 binding to repress MutSalpha expression in a p53 dependent manner ; Sp1 serves as a molecular switch by recruiting HIF-1alpha to the gene promoter under hypoxia
Cui et al., Cell 2007 (Carcinoma, Basal Cell...) : Here we provide biochemical and genetic evidence demonstrating that UV induction of POMC/MSH in skin is directly controlled by p53