◀ Back to TP53

EIF4E — TP53

Text-mined interactions from Literome

Zhu et al., Biochem Biophys Res Commun 2005 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : Here, we report that high level of eIF4E expression and its tumorigenicity could be alternatively associated with defects of p53, since we found that induction of wt-p53 repressed eIF4E expression ... Gene transfection of p53 inhibited eIF4E promoter activity, while inactivation of p53 either by mutation or by over-expression of MDM2 resulted in stimulation of eIF4E promoter activity ... These results suggest that the expression of eIF4E is reciprocally regulated by p53 and c-myc, and loss of p53 mediated control over c-myc dependent transactivation of eIF4E may represent a novel mechanism for eIF4E mediated neoplastic transformation and cancer progression
Wehbe et al., J Pharmacol Exp Ther 2006 (Bile Duct Neoplasms...) : The eukaryotic initiation factor 4E (eIF-4E) is overexpressed in many cancers, it can mediate sensitivity to therapy, and it may be regulated by p53 ... We examined the utility of pifithrin-alpha as an adjunct to therapy for the treatment of human cholangiocarcinoma, a tumor that is highly refractory to therapy, and we assessed the involvement of p53 dependent eIF-4E regulation in cellular responses to pifithrin-alpha