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IL1B — SOD1
Text-mined interactions from Literome
Laychock et al., Biochem Pharmacol 1998
(Insulinoma...) :
IL-1 beta also
increased cytosolic
Cu/Zn-superoxide dismutase ( SOD ) and mitochondrial Mn-SOD in RINm5F cells ... EA inhibited RINm5F cell
Cu/Zn-SOD in the
presence and absence of
IL-1 beta , whereas EA-S increased basal enzyme activity and did not affect the IL-1 beta response
Devaraj et al., Arterioscler Thromb Vasc Biol 1999
:
Although AT decreased superoxide release from activated monocytes,
superoxide dismutase and catalase
had no effect on
IL-1 beta release
Yamashita et al., J Exp Med 1999
(Myocardial Infarction...) :
The production of reactive oxygen species and endogenous TNF-alpha and
IL-1beta induced by exercise
leads to the activation of
Mn-SOD , which plays major roles in the acquisition of biphasic cardioprotection against ischemia/reperfusion injury in rats
Xu et al., DNA Cell Biol 1999
:
An intronic NF-kappaB element is essential for
induction of the human manganese
superoxide dismutase gene by tumor necrosis factor-alpha and
interleukin-1beta
Boisclair et al., J Biol Chem 2000
:
IL-1beta reduced the ability of GH to stimulate ALS mRNA in rat primary hepatocytes and
ALS promoter activity in H4-II-E rat hepatoma cells
Pavlovic et al., Eur Cytokine Netw 2000
(Diabetes Mellitus, Type 1) :
When added together, p38i and MEKi decreased IL-1 beta induced nitrite production over 24 hours by 60 %, but did not affect
IL-1 beta induced manganese
superoxide dismutase ( MnSOD ) mRNA expression
Yamashita et al., Br J Pharmacol 2000
(Myocardial Reperfusion Injury...) :
We conclude that the induction and activation of
Mn-SOD ,
mediated by TNF-alpha and
IL-1beta after IP, plays an important role in the acquisition of late-phase cardioprotection against ischaemia/reperfusion injury in rats
Kelly et al., J Biol Chem 2001
:
We observed that IL-10 abrogated the stimulatory
effect of
IL-1 beta on
superoxide dismutase activity and reactive oxygen species production, whereas the H ( 2 ) O ( 2 ) -induced inhibition of LTP was also blocked by IL-10
Borg et al., Endocrinology 1992
:
Interleukin-1 beta increases the activity of
superoxide dismutase in rat pancreatic islets ... Presently, the
effects of human recombinant
IL-1 beta ( rIL-1 beta ) on the activities of
superoxide dismutase ( SOD ) and the expression of corresponding genes were studied in rat pancreatic islets
Feng et al., Chin J Physiol 2004
(Lung Diseases) :
However, only
SOD + CAT and vitamin C
inhibited the mRNA expression of
IL-1beta
Mathy-Hartert et al., Osteoarthritis Cartilage 2008
:
In parallel,
IL-1beta markedly
enhanced Mn
SOD and GPX gene expressions, but decreased Cu/Zn SOD, EC SOD and CAT gene expressions
Qiu et al., J Biol Chem 2008
(Inflammation) :
Induction of
Mn-SOD gene expression by the proinflammatory cytokine
IL-1beta is mediated through a complex intronic enhancer element
Meissner et al., Proc Natl Acad Sci U S A 2010
(Amyotrophic Lateral Sclerosis...) :
We report that ALS linked mutant
superoxide dismutase 1 (SOD1) activates caspase-1 and
IL-1beta in microglia ... Notably, mutant
SOD1 induced
IL-1beta correlated with amyloid-like misfolding and was independent of dismutase activity
Deng et al., Zhongguo Zhong Xi Yi Jie He Za Zhi 2012
(Lung Injury) :
Compared with the control group, the wet weight-dry weight ratio was reduced and the permeability of the lung tissue decreased ( P < 0.05 ), the MDA content was reduced, the activity of MPO decreased, and the activity of
T-SOD increased ( P < 0.05 ), and the levels of
IL-1beta , IL-8, and PAF obviously decreased ( P < 0.05 )
Kayanoki et al., J Biol Chem 1994
:
While
interleukin-1 beta and interleukin-6
induced manganese-superoxide dismutase gene expression, they slightly suppressed catalase gene expression in rat hepatocytes
Bedoya et al., Biochem Biophys Res Commun 1995
(Insulinoma...) :
We presently investigated the effects of pyrrolidine dithiocarbamate ( PDTC ), a potent inhibitor of nuclear factor kappa B (NF-kappa B), on the
induction of nitric oxide synthase ( iNOS ) and manganese
superoxide dismutase ( MnSOD ) mRNAs by
IL-1 beta in insulin producing RIN cells
Troy et al., Proc Natl Acad Sci U S A 1996
:
SOD1 down-regulation
results in an increase in
interleukin 1beta (IL- 1beta) production by the cells, and cell death under these conditions can be prevented by either blocking antibodies against IL-1beta or the IL-1 receptor antagonist ( IL-1Ralpha )
Strandell et al., Immunol Lett 1995
:
Interleukin-1 beta induces the expression of hsp70, heme oxygenase and
Mn-SOD in FACS purified rat islet beta-cells, but not in alpha-cells
Antras-Ferry et al., FEBS Lett 1997
:
IL-1beta and TNF-alpha both
stimulated specifically
Mn-SOD gene expression in a time dependent manner ... TNF-alpha rapidly
induced Mn-SOD gene expression while
IL-1beta was a strong but slow inducer of this gene ... Dexamethasone prevented the TNF-alpha- but not the
IL-1beta induced up-regulation of
Mn-SOD gene transcription by a mechanism likely to involve the glucocorticoid receptor ... These results suggest that
IL-1beta and TNF-alpha
regulate Mn-SOD gene transcription by different pathways
Jones et al., Mol Cell Biol 1997
:
Tumor necrosis factor alpha and
interleukin-1beta regulate the murine manganese
superoxide dismutase gene through a complex intronic enhancer involving C/EBP-beta and NF-kappaB
Delhanty et al., Biochem Biophys Res Commun 1998
:
However, under basal conditions
IL-1 beta had no significant effect on
ALS mRNA levels, and only a slight suppression of secretion ... Our study suggests that
IL-1 beta regulates
ALS gene expression and secretion in a way that is dependent, in part, on interaction with the GH signalling pathway