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IL1B — MIF

Text-mined interactions from Literome

Hines et al., Vet Microbiol 1999 : MIF-A3 does induce secretion of IL-6, but does not induce secretion of TNFalpha, IL-1beta , and GM-CSF
Leech et al., Arthritis Rheum 1999 (Arthritis, Rheumatoid) : Synoviocyte MIF was not increased by IL-1beta , TNFalpha, or IFNgamma
Kariya et al., Clin Diagn Lab Immunol 2003 (Otitis Media with Effusion) : MIF was detected in 97.9 % of the MEEs from adults, while endotoxin, IL-1beta , TNF-alpha, and RANTES were detected in 96.8, 12.6, 5.3, and 43.9 %, respectively
Onodera et al., Arthritis Rheum 2004 (Arthritis, Rheumatoid...) : MIF induced IL-8 and IL-1beta transcriptional activation was studied in RA synovial fibroblasts by Northern blot analysis, enzyme linked immunosorbent assay, and electromobility shift assay ... The mRNA up-regulation of IL-8 and IL-1beta by MIF was inhibited by 2 tyrosine kinase inhibitors, a protein kinase C ( PKC ) inhibitor, an activator protein 1 (AP-1) inhibitor, and by an NF-kappaB inhibitor
Cao et al., Biol Reprod 2005 : Curcumin ( 10 ( -8 ) M ), which is known for inhibiting NFkappaB activation, inhibited IL1B induced MIF secretion as well as NFkappaB nuclear translocation and DNA binding
Kariya et al., Am J Rhinol 2005 (Mucocele...) : MIF and endotoxin were detected in the fluid of all samples, whereas interleukin-1beta and RANTES were detected in 1 and 3 subjects out of 12 samples
Herrmann Lavoie et al., Am J Reprod Immunol 2007 (Endometriosis) : Interleukin-1beta acts rapidly on endometriotic cells and stimulated MIF secretion and mRNA steady-state levels in a dose and time dependent manner
Honda et al., J Dermatol Sci 2008 : IL-1beta is involved in the up-regulation of UVA induced MMP-1 in dermal fibroblasts, and IL-1beta and MIF cytokine network induce MMP-1 and contribute to the loss of interstitial collagen in skin photoaging
Veillat et al., Fertil Steril 2009 (Endometriosis...) : This study showed a significant dose dependent increase of MIF protein secretion and mRNA expression, the NF-kappaB translocation into the nucleus, I kappaB phosphorylation, I kappaB degradation, and human MIF promoter activity in endometriotic stromal cells in response to IL-1 beta
Balachandran et al., Bioorg Med Chem Lett 2009 : Of note, compounds 7, 22, 23, 24, 25 and 27 inhibited the spontaneous secretion/release/recognition of MIF from freshly isolated human peripheral blood mononuclear cells and, more importantly, inhibited the MIF induced production of interleukin-6 (IL-6) and/or interleukin-1beta (IL-1beta) significantly better than ISO-1