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ELAVL1 — PRKAB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Wang et al., Mol Cell Biol 2002
:
Here, we report that the
AMP activated kinase (AMPK) , an enzyme involved in responding to metabolic stresses, potently
regulates the levels of cytoplasmic
HuR ... Conversely,
AMPK activation, achieved by means including infection to express constitutively active AMPK,
resulted in reduced cytoplasmic
HuR ; decreased levels and half-lives of mRNAs encoding p21, cyclin A, and cyclin B1 ; and diminished HuR association with the corresponding transcripts
Di Marco et al., Mol Cell Biol 2005
(Wasting Syndrome) :
Moreover, we show that
HuR regulates iNOS expression in an
AMP activated protein kinase (AMPK) dependent manner ... Furthermore,
AMPK activation
results in
HuR nuclear sequestration, inhibition of iNOS synthesis, and reduction in cytokine induced MyoD loss
Zou et al., Biochem J 2008
:
AMPK activation by overexpression of the AMPK gene increased Impalpha1 but
reduced the cytoplasmic levels of
HuR in control and polyamine-deficient cells ... These results indicate that polyamine mediated
AMPK activation triggers HuR nuclear import through phosphorylation and acetylation of Impalpha1 in IECs and that polyamine depletion
increases cytoplasmic levels of
HuR as a result of inactivation of the AMPK-driven Impalpha1 pathway