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MMP3 — SLC22A3
Text-mined interactions from Literome
Radisky et al., Nature 2005
(Cell Transformation, Neoplastic...) :
Rac1b and reactive oxygen species mediate
MMP-3 induced
EMT and genomic instability ... We have previously investigated stromelysin-1/matrix metalloproteinase-3 (MMP-3), a stromal enzyme upregulated in many breast tumours, and found that
MMP-3 can
cause epithelial-mesenchymal transition (EMT) and malignant transformation in cultured cells, and genomically unstable mammary carcinomas in transgenic mice
Przybylo et al., Int J Biochem Cell Biol 2007
(Disease Progression...) :
MMP-3 induced
EMT involves induction of Snail, a transcription factor long studied for its role in physiological EMT but which is increasingly recognized as a factor involved in tumor progression and malignancy
Stallings-Mann et al., Cells Tissues Organs 2007
(Cell Transformation, Neoplastic) :
We have identified the induction of Rac1b, an alternatively spliced variant of Rac1, as a key event in
MMP induced
EMT
Nelson et al., J Cell Biochem 2008
:
We had shown previously that
matrix metalloproteinase-3 (MMP3) can
stimulate EMT of cultured mouse mammary epithelial cells through a process that involves increased expression of Rac1b, a protein that stimulates alterations in cytoskeletal structure ... We show here that cells treated with MMP-3 or induced to express Rac1b spread to cover a larger surface, and that this induction of cell spreading is a requirement of
MMP-3/Rac1b induced
EMT
Lee et al., Carcinogenesis 2008
(Breast Neoplasms...) :
Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances
EMT induced by TGF-beta in mammary epithelial cells via a
MMP dependent mechanism
Tan et al., Am J Pathol 2010
(Fibrosis...) :
AMCM induced tubular cell
EMT in C1.1 cells was
inhibited by broad-spectrum
MMP inhibitor ( GM6001 ), MMP-2/9 inhibitor, and in AMCM after MMP-9 removal by monoclonal Ab against MMP-9 ... Furthermore,
MMP-9 induced tubular cell
EMT in C1.1 cells to an extent similar to transforming growth factor-beta