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IL12B — TSLP

Text-mined interactions from Literome

Watanabe et al., Blood 2005 (Dermatitis, Atopic...) : Human TSLP promotes CD40 ligand induced IL-12 production by myeloid dendritic cells but maintains their Th2 priming potential
Ito et al., J Exp Med 2005 : Here we report that TSLP induced human DCs to express OX40 ligand (OX40L) but not IL-12
Tanaka et al., Clin Exp Allergy 2009 : Although TSLP alone did not induce IL-23 production by DCs, poly ( I : C ) alone primed DCs for the production of IL-23, and a combination of TSLP and poly ( I : C ) primed DCs for further production of IL-23
Massacand et al., Proc Natl Acad Sci U S A 2009 (Strongylida Infections...) : TSLP inhibited IL-12p40 production in response to T. muris infection, and treatment of TSLPR ( -/- ) animals with neutralizing anti-IL-12p40 monoclonal antibody ( mAb ) was able to reverse susceptibility and attenuate IFN-gamma production ... Taken together, our data show that the primary function of TSLP is to directly suppress IL-12 secretion, thus supporting Th2 immune responses
Chu et al., J Allergy Clin Immunol 2013 (Hypersensitivity) : We showed that experimental HDM induced allergic asthma and food allergy and anaphylaxis to peanut were associated with TSLP production but developed independently of TSLP, likely because these allergens functionally mimicked TSLP inhibition of IL-12 production and induction of OX40 ligand (OX40L) on DCs