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EGF — MAP3K2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Sun et al., Mol Cell Biol 2003
:
Activation of
MEKK2 and the ERK5 pathway by
EGF and stress stimuli is dependent on Src kinase activity ... JNK activation by
EGF is similarly
inhibited by loss of Lad or MEKK2 expression and by blocking the interaction of
MEKK2 and Lad ... Our studies demonstrate that Src kinase activity is required for ERK5 activation in response to EGF, MEKK2 expression is required for ERK5 activation by Src, Lad and MEKK2 association is required for Src activation of ERK5, and
EGF and Src stimulation of ERK5 regulated MEF2 dependent promoter activity
requires a functional
Lad-MEKK2 signaling complex
Yao et al., PloS one 2010
(MAP Kinase Signaling System) :
In addition, we found that changes in calcium levels affect the
EGF induced nuclear translocation of
MEKK2 and thereby its effect on the nuclear ERK5 activity