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PNMT — SP1

Text-mined interactions from Literome

Her et al., J Biol Chem 1999 : Furthermore, activation of the PNMT promoter by Sp1 depends on both its binding affinity for its cognate target sequences and its intracellular concentrations ... Finally, another transcription factor expressed in the Neuro2A cells competes with Sp1 by interacting with DNA sequences 3 ' to the -48 base pair Sp1 site to prevent Sp1 binding and induction of the PNMT promoter ... These findings suggest that Sp1 may potentially contribute to the tissue-specific expression of the PNMT gene, with the competition between Sp1 and MAZ conferring additional tissue-specific control
Her et al., Mol Pharmacol 2003 : In transfection assays, PNMT promoter activation by Sp1 and MAZ depends on promoter length, with -893 bp of sequence yielding greatest activation
Wong et al., Ann N Y Acad Sci 2008 : Induction of both appear mediated via activation of multiple signaling pathways and downstream activation of hypoxia inducible factor and PNMT transcriptional activators, Egr-1 and Sp1
Nguyen et al., Neurosci Lett 2009 (Hypertension) : The PNMT gene is highly regulated by key transcription factors including : Egr-1, Sp1 , AP-2 and the glucocorticoid receptor
Ebert et al., J Biol Chem 1995 : Differential activation of the rat phenylethanolamine N-methyltransferase gene by Sp1 and Egr-1