Park et al., J Biol Chem 2002
:
Akt ( protein kinase B ) negatively regulates SEK1 by means of protein phosphorylation ... Expression of a constitutively active form of Akt also inhibited both SEK1 and JNK1 activation, but not that of MEKK1, in transfected 293T cells
Baudhuin et al., Mol Pharmacol 2002
:
Akt activation induced by lysophosphatidic acid and sphingosine-1-phosphate requires both mitogen activated protein kinase kinase and p38 mitogen activated protein kinase and is cell-line specific
Dai et al., Blood 2005
(Acute Disease...) :
Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK Imarisio et al., Clin Sci (Lond) 2012
(Fatty Liver) :
CGS21680 action required PI3K ( phosphoinositide 3-kinase ) /Akt mediated block of MKK4/SEK1