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HSPA5 — IGF1

Text-mined interactions from Literome

Novosyadlyy et al., Cell Death Differ 2008 : During ER stress, IGF-I stimulates translational recovery and induces expression of the key molecular chaperone protein Grp78/BiP , thereby enhancing the folding capacity of the ER and promoting recovery from ER stress ... During ER stress, IGF-I stimulates translational recovery and induces expression of the key molecular chaperone protein Grp78/BiP , thereby enhancing the folding capacity of the ER and promoting recovery from ER stress
Pfaffenbach et al., J Cell Physiol 2012 : In this study, we examined the regulation of GRP78 in response to reduced IGF-1 growth factor signaling, a common consequence of calorie restriction ( CR ) ... In conclusion, we report that IGF-1 receptor signaling regulates GRP78 expression via the PI3K/AKT/mTORC1 axis independent of the canonical UPR and FOXO1