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BTK — TLR5
Text-mined interactions from Literome
Schmidt et al., J Immunol 2006
:
Recent evidence has also supported a
role for
Btk in
TLR signaling
Jyonouchi et al., Eur J Pediatr 2008
(Deafness...) :
Moreover, BTK null cells from these patients exhibited robust responses to TLR agonists, normal natural killer ( NK ) cell activity, and normal pDC functions.CONCLUSION : Our results do not indicate the essential
role of
Btk in
TLR signaling and DC development
Taneichi et al., Clin Immunol 2008
(Agammaglobulinemia...) :
These findings suggest that
BTK may thus be
required for
TLR signaling in DCs
Marron et al., Clin Immunol 2010
(Agammaglobulinemia...) :
Bruton's tyrosine kinase (Btk) has been reported to mediate signaling through toll-like receptors ( TLRs ) in many cell types, however, the
role of
Btk in
TLR activation of neutrophils remains unclear
Liu et al., Nat Immunol 2011
(Sepsis) :
Then,
Btk interacted with the adaptor molecules MyD88 and TRIF and thereby
promoted TLR signaling