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ATP5O — NPPA
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Haverkamp et al., Vis Neurosci 1999
:
It is possible that the
gamma-ANP may be
involved in regulating the activity of Na+/K+
ATPase or in the modulation of cGMP levels
Caruso-Neves et al., Biochim Biophys Acta 2004
:
In the present paper we studied the
effect of urodilatin and
atrial natriuretic peptide (ANP) on the proximal tubule
Na+-ATPase and ( Na+K+ ) ATPase activities ... Urodilatin and
ANP inhibit the Na+-ATPase activity but not the ( Na+K+ )
ATPase activity
Fedorova et al., Hypertension 2006
:
We studied
effects of
ANP on
Na/K-ATPase phosphorylation and inhibition by an endogenous sodium pump ligand, marinobufagenin, in the aorta and renal medulla from male Sprague-Dawley rats ... Marinobufagenin ( 1 nmol/L ) inhibited Na/K-ATPase in aortic sarcolemma ( 18 % ) and in renal medulla ( 19 % ).
prepro-ANP 104 to 123 ( ppANP ) and alpha-human ANP ( [ alpha-hANP ] both 1 nmol/L )
potentiated marinobufagenin induced
Na/K-ATPase inhibition in the kidney, but reversed the effect of marinobufagenin in the aorta
Mills et al., Klin Wochenschr 1987
:
Since
ANP stimulates increased kallikrein release in rats and does not
inhibit Na/K
ATPase , it is suggested that the natriuretic pathway via inhibition of renal Na/K ATPase is independent in the kidney of the kallikrein/kinin natriuretic pathway
Zeidel et al., Clin Exp Pharmacol Physiol 1995
:
Rather,
ANP 31-67
inhibits basolateral
Na/K-ATPase , probably via the stimulation of PGE2 synthesis