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BMP7 — SMN1
Text-mined interactions from Literome
Chalazonitis et al., J Neurosci 2004
:
When applied to immunopurified E12 ENS precursors,
BMP-2 and BMP-4
induced nuclear translocation of phosphorylated Smad-1 (
Sma and Mad related protein )
Matsui et al., Dev Growth Differ 2008
:
During heart development at the gastrula stage, inhibition of
bone morphogenetic protein ( BMP ) activity affects the heart specification but does not
impair the expression of
smooth muscle alpha-actin (SMA) , which is first expressed in the heart mesoderm and recruited into initial heart myofibrils
Zhou et al., Zhongguo Zhong Yao Za Zhi 2010
:
BMP-7 significantly
inhibited the down-regulation of E-cadherin and the up-regulation of
alpha-SMA induced by TGF-beta1 ( P < 0.05 ), and SA-B significantly inhibited the up-regulation of alpha-SMA expression induced by TGF-beta1 ( P < 0.05 ), but not the down-regulation of E-cadherin induced by TGF-beta1
Wang et al., Stem Cells Dev 2012
:
Exploring the molecular basis for this effect, we found that restricting cell spreading, reducing ROCK signaling, or inhibiting cytoskeletal tension prevented
BMP induced
SMA/mothers against decapentaplegic ( SMAD)1 c-terminal phosphorylation, SMAD1 dimerization with SMAD4, and SMAD1 translocation into the nucleus