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IFNAR1 — IFNB1

Pathways - manually collected, often from reviews:

• BioCarta bone remodeling: IFNAR1/IFNAR2 complex (IFNAR1-IFNAR2) → IFN-beta (IFNB1) (modification, collaborate)
• BioCarta bone remodeling: IFNAR1/IFNAR2 complex (IFNAR1-IFNAR2) → IFN-beta/IFNAR1/IFNAR2 complex (IFNB1-IFNAR1-IFNAR2) (modification, collaborate)
  
• BioCarta bone remodeling: IFN-beta (IFNB1) → IFN-beta/IFNAR1/IFNAR2 complex (IFNB1-IFNAR1-IFNAR2) (modification, collaborate)
  
• BioCarta ifn alpha signaling pathway: IFNAR2/TYK2 complex (TYK2-IFNAR2) → IFN-beta/IFNAR1/IFNAR2/JAK1/TYK2 complex (IFNB1-TYK2-IFNAR2-IFNAR1-JAK1) (modification, collaborate)
  
• BioCarta ifn alpha signaling pathway: IFN-beta (IFNB1) → IFN-beta/IFNAR1/IFNAR2/JAK1/TYK2 complex (IFNB1-TYK2-IFNAR2-IFNAR1-JAK1) (modification, collaborate)
  
• BioCarta ifn alpha signaling pathway: IFN-beta (IFNB1) → IFNAR1/JAK1 complex (IFNAR1-JAK1) (modification, collaborate)
  
• BioCarta ifn alpha signaling pathway: IFN-beta/IFNAR1/IFNAR2/JAK1/TYK2 complex (IFNB1-TYK2-IFNAR2-IFNAR1-JAK1) → IFNAR1/JAK1 complex (IFNAR1-JAK1) (modification, collaborate)
  
• KEGG Osteoclast differentiation: IFNB1 → IFNAR1/IFNAR2 (protein-protein, activation)
• KEGG Toll-like receptor signaling pathway: IFNB1 → IFNAR1/IFNAR2 (protein-protein, activation)
• KEGG Natural killer cell mediated cytotoxicity: IFNA1/IFNA10/IFNA13/IFNA14/IFNA16/IFNA17/IFNA2/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/IFNA8/IFNB1/IFNG → IFNAR1/IFNAR2/IFNGR1/IFNGR2 (protein-protein, activation)
  
• KEGG Hepatitis C: IFNA1/IFNA10/IFNA13/IFNA14/IFNA16/IFNA17/IFNA2/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/IFNA8/IFNB1 → Complex of IFNAR1-IFNAR2 (protein-protein, activation)
• KEGG Measles: IFNA1/IFNA10/IFNA13/IFNA14/IFNA16/IFNA17/IFNA2/IFNA21/IFNA4/IFNA5/IFNA6/IFNA7/IFNA8/IFNB1 → IFNAR1/IFNAR2 (protein-protein, activation)
• KEGG Influenza A: IFNB1 → IFNAR1/IFNAR2 (protein-protein, binding/association)
• KEGG Cytokine-cytokine receptor interaction: IFNB1 → Complex of IFNAR1-IFNAR2 (protein-protein, activation)
• Reactome Reaction: IFNB1 → IFNAR1 (indirect_complex) You et al., Mol Cell Biol 1999, Rani et al., J Biol Chem 1999, Mowen et al., Mol Cell Biol 2000, Myers et al., J Biol Chem 2001, Lamken et al., J Mol Biol 2004, Cajean-Feroldi et al., Biochemistry 2004, Roisman et al., J Mol Biol 2005, Geiger et al., J Virol 2006, Uzé et al., Curr Top Microbiol Immunol 2007, Xu et al., Frontiers in bioscience : a journal and virtual library 2008, Colamonici et al., Mol Cell Biol 1994, Improta et al., Proc Natl Acad Sci U S A 1994, Müller et al., Nature 1993, Yan et al., EMBO J 1996, Gauzzi et al., J Biol Chem 1996, Jiao et al., Mol Cell Biol 1996, Domanski et al., J Biol Chem 1997
• Reactome Reaction: IFNB1 → IFNAR1 (reaction) Rani et al., J Biol Chem 1999, Mowen et al., Mol Cell Biol 2000, Lamken et al., J Mol Biol 2004, Cajean-Feroldi et al., Biochemistry 2004, Roisman et al., J Mol Biol 2005, Geiger et al., J Virol 2006, Uzé et al., Curr Top Microbiol Immunol 2007, Colamonici et al., Mol Cell Biol 1994, Improta et al., Proc Natl Acad Sci U S A 1994, Müller et al., Nature 1993, Yan et al., EMBO J 1996, Gauzzi et al., J Biol Chem 1996, Domanski et al., J Biol Chem 1997
• WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway: CSF3/EPO/IFNA7/CSH1/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNA7/IFNB1/IL2/OSM/PRL/IFNA7/IFNA7 → IL3RA/IL2RB/IFNAR1/OSMR/PRLR/IL7R/IL6R/CSF3R/IL2RA/EPOR/IL4R/IL2RG/IFNAR2/GHR (activation)
  
• WikiPathways Regulation of toll-like receptor signaling pathway: IFNB1 → IFNAR1/IFNAR2 (activation)
• WikiPathways Toll-like Receptor Signaling Pathway: IFNB1 → IFNAR1/IFNAR2 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• MIPS CORUM IFNB1-IFNAR1-IFNAR2- complex: IFNB1-IFNAR1-IFNAR2- complex complex (IFNAR1-IFNAR2-IFNB1) Arduini et al., Protein Sci 1999*
• IRef Corum Interaction: Complex of IFNAR2-IFNAR1-IFNB1 (association, cross-linking study) Arduini et al., Protein Sci 1999*
• IRef Dip Interaction: IFNAR1 — IFNB1 (physical association, coimmunoprecipitation) Russell-Harde et al., Biochem Biophys Res Commun 1999*
• IRef Dip Interaction: IFNAR1 — IFNB1 (physical association, biochemical) Russell-Harde et al., J Biol Chem 1995*
• IRef Hprd Interaction: IFNAR1 — IFNB1 (in vivo) Flores et al., J Biol Chem 1991*
• IRef Ophid Interaction: IFNAR1 — IFNB1 (aggregation, confirmational text mining) Flores et al., J Biol Chem 1991*
• IRef Ophid Interaction: IFNAR1 — IFNB1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Rani et al., J Biol Chem 1999 : Additionally, IFN-beta mediated phosphorylation of interferon-alpha receptor-1 (IFNAR-1) was defective in IFN-beta treated U1.KR930 cells, but evident in U1.wt cells ... Our results indicate that catalytically active TYK2 is required for IFN-beta mediated tyrosine phosphorylation of STAT3 and IFNAR-1 in intact cells
Heinz et al., J Biol Chem 2003 : In murine macrophages, IFN-beta induced TLR3 up-regulation required IFNAR1 , STAT1, and in part IRF-1, but not the Janus kinase ( Jak ) family member Tyk2
Schmidt et al., Exp Neurol 2009 (Demyelinating Diseases...) : We demonstrate that IFNAR signalling was induced during acute demyelination since the cytokine IFN-beta as well as the IFN dependent genes IRF7, ISG15 and UBP43 were strongly upregulated