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GLI2 — RUNX2
Text-mined interactions from Literome
Shimoyama et al., Mol Biol Cell 2007
:
Ihh treatment or
Gli2 overexpression also
up-regulated the expression of
Runx2 , an essential transcription factor for osteoblastogenesis, and enhanced the transcriptional activity and osteogenic action of Runx2 ... Collectively, these results suggest that Ihh regulates osteoblast differentiation of mesenchymal cells through
up-regulation of the expression and function of
Runx2 by
Gli2
Qiu et al., PloS one 2010
:
Our findings suggest a role for Pkd1 and Kif3a to counterbalance the regulation of osteogenesis and adipogenesis through differential
regulation of
Runx2 and PPAR? by
Gli2