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FAS — TP53

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: FAS → TP53 (increases, FAS Activity)
  Evidence: NF?B family transcription factors can induce expression of antiapoptotic proteins that oppose the intrinsic (Bcl-XL, Bfl-1), extrinsic (FLIP), and convergence (cIAP2) pathways (Figure 2A), as well as suppressing expression of the death inducer Bax (intrinsic pathway) in some types of tumor cells (Karin and Lin, 2002). Further, hyperactivity of NF?B is now well documented in certain cancers (Karin et al., 2002).
• OpenBEL Selventa BEL large corpus: FAS → TP53 (increases, FAS Activity) Bartke et al., Oncogene 2001*
  Evidence: Treatment of p53 induces 3-4 fold upregulation of TRAIL-R2 and Fas mRNA but not upon induction of p53-R175H.
• OpenBEL Selventa BEL large corpus: FAS → TP53 (increases, FAS Activity)
  Evidence: These two BH3-only proteins interact with BCL2 survival proteins to induce mitochondriadependent cell death. In addition, p53 also induces the expression of other components of the apoptotic or deathreceptor signaling such as apoptotic peptidase activating factor 1 (APAF1), caspase 6 or FAS.
• KEGG p53 signaling pathway: TP53 → FAS (gene expression, expression)
• WikiPathways miRNA Regulation of DNA Damage Response: TP53 → Complex of FAS-PIDD1-TNFRSF10B (activation)
  
• WikiPathways DNA Damage Response: TP53 → Complex of FAS-PIDD1-TNFRSF10B (activation)
  

Text-mined interactions from Literome

Chen et al., Biochem Biophys Res Commun 1999 : Lack of correlation in JNK activation and p53 dependent Fas expression induced by apoptotic stimuli ... Induction of Fas expression by DNA damaging agents is dependent on the expression of functional p53 , and has been suggested to play an important role in apoptosis induction
Kobayashi et al., Cell Death Differ 1998 : It has been reported that p53 upregulates Fas/APO-1 and Bax expression ... These results suggest that functional p53 is necessary for the activation of Bax and Fas/APO-1 expression
Ruiz-Ruiz et al., Cell Death Differ 1999 (Breast Neoplasms) : p53 mediated up-regulation of CD95 is not involved in genotoxic drug induced apoptosis of human breast tumor cells
Pohl et al., Cell Physiol Biochem 1999 (Brain Neoplasms...) : p53 enhances BAK and CD95 expression in human malignant glioma cells but does not enhance CD95L induced apoptosis ... Wild-type, but not mutant, p53val135 enhanced CD95 expression in all cell lines ... Thus, wild-type p53 induces BAK and CD95 expression in human glioma cells without enhancing their susceptibility to CD95 mediated apoptosis, and mutant p53 modulates CD95L evoked apoptotic signalling in a gain-of-function fashion up-stream and down-stream of caspase 3 activation
Beltinger et al., Proc Natl Acad Sci U S A 1999 : Here we show that TK/GCV treatment induces p53 accumulation and increases cell surface expression of CD95 and tumor necrosis factor receptor, which is likely to involve p53 mediated translocation of CD95 to the cell surface
Munsch et al., J Biol Chem 2000 : We propose that p53 dependent up-regulation of Fas does not induce apoptosis per se but sensitizes the cell to other pro-apoptotic signal ( s ) ... The functional conservation of p53 dependent Fas up-regulation argues strongly in favor of its biological importance and suggests that murine models may be used to study further the in vivo role of Fas in the p53 response
Sheikh et al., Leukemia 2000 : Recent evidence suggests that p53 upregulates the expression of death receptors Fas and DR5, and thus, may mediate apoptosis in part via Fas and/or DR5
Gutiérrez del Arroyo et al., Oncogene 2000 : Involvement of p53 and interleukin 3 in the up-regulation of CD95 ( APO-1/Fas ) by X-ray irradiation
Hara et al., Prostate 2000 (Prostatic Neoplasms) : The effects of adenovirus mediated p53 gene transfer ( Ad5CMV-p53 ) into human prostate cancer LNCaP, DU145, and PC3 cells on their growth, apoptosis and Fas receptor/ligand expression were examined by the MTT assay, DNA fragmentation assay, and Northern blot analysis, respectively
Sun et al., Cancer Res 2000 (Carcinoma, Non-Small-Cell Lung...) : These results implicate the involvement of wild-type p53 in CD437 induced Fas expression in human NSCLC cells
Volkmann et al., J Mol Med (Berl) 2001 (Carcinoma, Hepatocellular...) : Experimental data have shown p53 dependent CD95 induction to be associated with increased levels of apoptosis after cytostatic treatment in hepatoma cells
Timmer et al., J Pathol 2002 (Neoplasms, Experimental) : However, the role of wild-type p53 in Fas expression is still controversial
Sheard et al., Oncogene 2002 (Adenocarcinoma...) : We show that, subsequent to sequestration and inactivation of the p53 tumour suppressor protein, SV40 abrogates p53 dependent , DNA damage-inducible up-regulation of CD95 surface expression
Shinoura et al., Br J Cancer 2002 (Brain Neoplasms...) : Induction of wild type p53 enhanced the expression levels of Bax, p21/WAF1, and Fas protein ... This suggests that induction of wild type p53 upregulates Fas , which in turn may play a role in the activation of Apaf-1 and caspase-9
Kim et al., Biochem Pharmacol 2002 (Leukemia) : This induction of Fas was not dependent upon p53 , because p53 is not expressed in an active form in either HL-60 or MOLT-4 cells
Lin et al., Int J Oncol 2002 : Tissue-specific regulation of Fas/APO-1/CD95 expression by p53 ... These data indicate that p53 regulates Fas expression in a tissue-specific manner
Fujita et al., Am J Respir Cell Mol Biol 2002 : Expression of dominant negative p53 also inhibited the Fas translocation induced by H ( 2 ) O ( 2 ) in A549 cells
Ando et al., Microsc Res Tech 2002 : Hepatocytes that were immunoreactive for p53 had slightly increased with aging, suggesting that p53 may mediate the age enhanced up-regulation of Fas receptor in hepatocytes
Kuwano et al., Lab Invest 2002 (Lung Diseases, Interstitial) : Fas ligation induces apoptosis of lung epithelial cells predominantly through the direct activation of the caspase cascade via caspase-8 activation, whereas the up-regulation of p53 and other cellular stresses can induce mitochondria mediated apoptosis
Ruiz-Ruiz et al., J Biol Chem 2003 (Breast Neoplasms) : Characterization of p53 mediated up-regulation of CD95 gene expression upon genotoxic treatment in human breast tumor cells ... On the other hand, Bcl-2 overexpression albeit preventing doxorubicin induced apoptosis, has no effect on p53 mediated CD95 up-regulation in breast tumor cells
Zalcenstein et al., Oncogene 2003 : Excess mutant p53 represses the transcriptional activity of the CD95 promoter, with the extent of repression varying among different tumor associated p53 mutants
Sheard et al., Cancer Res 2003 (Breast Neoplasms) : Role of p53 in regulating constitutive and X-radiation-inducible CD95 expression and function in carcinoma cells ... However, whether p53 dependent regulation of CD95 expression is consistently associated with increased susceptibility to CD95 mediated cell death is poorly understood
Gu et al., Oncogene 2004 (Carcinoma, Non-Small-Cell Lung...) : We found that Ad/p53 induced the expression of the proapoptotic genes PUMA, Bak, Bax, and Fas in a cell type- and time dependent manner
Cerrato et al., Int J Oncol 2004 (Brain Neoplasms...) : Use of the protein transport inhibitor Brefeldin A significantly inhibited Ad-p53 induced surface Fas/CD95 expression, but only partially inhibited apoptosis in mutant-p53 cell lines ... These results suggest that p53 regulates Fas/CD95 expression at the transcriptional level and through protein trafficking in mutant-p53 cell lines
Menendez et al., Int J Oncol 2004 (Breast Neoplasms) : In SK-Br3 cells, cerulenin induced inhibition of FAS activity resulted in down-regulation of p53 , and up-regulation of cyclin dependent kinase inhibitor (CDKi) p21WAF1/CIP1
Kim et al., Biochem Biophys Res Commun 2004 (Adenoviridae Infections...) : The finding that Adp14ARF infection did not induce Fas expression in U2OS/E6 and MCF/E6 cells suggests that wild type p53 expression may be necessary for Adp14ARF mediated induction of Fas ... The observation that overexpression of p53 by Adp53 infection in MCF-7 does not induce increased Fas protein levels nor apoptotic cell death suggests that p53 overexpression is required but not sufficient enough for apoptosis
Yada et al., J Immunol 2005 (Acute Disease...) : Our data indicate that BM depletion in acute GVHD is mediated by p53 dependent up-regulation of Fas on BMC, which leads to Fas dependent depletion and subsequent disease
Martin et al., J Neurosci 2005 (Amyotrophic Lateral Sclerosis...) : Fas upregulation was p53 dependent
Le Clorennec et al., Blood 2006 (Cell Transformation, Viral...) : Epstein-Barr virus ( EBV ) induces CD95 expression and the CD95 gene ( FAS ) is regulated by NF-kappaB, STAT1, and/or p53
Senatus et al., Mol Cancer Ther 2006 (Central Nervous System Neoplasms...) : p53p-Ant induced a 3-fold increase in extracellular membrane Fas expression in glioma cells but no significant increase in nonmalignant glial cells
Liu et al., Cell Death Differ 2007 : However, we found that Fas/CD95 was significantly induced in response to hypoxia in a p53 dependent manner, along with several novel p53 target genes including ANXA1, DDIT3/GADD153 ( CHOP ), SEL1L and SMURF1
Rho et al., Cancer Res 2007 (Carcinoma, Non-Small-Cell Lung...) : Conversely, inhibition of p53 using antisense oligonucleotide in A549 caused a significant decrease in apoptosis by gefitinib and down-regulation of Fas under the same conditions
Okazaki et al., J Cancer Res Clin Oncol 2007 (Disease Models, Animal...) : By Northern blot and Western blot analyses, we determined the effect of p53 on the FasL and Fas receptor expression
Amano et al., J Neurooncol 2009 (Brain Neoplasms...) : Mechanistically, Ad-p53 was capable only of increasing the expression of p21/CIP, whereas Ad-p53-15D20D increased the binding to and expression of the pro-apoptotic genes Fas , Puma and PIG3
Schilling et al., Biochem Biophys Res Commun 2010 (Carcinoma, Hepatocellular...) : This is due to repression of CD95 gene transcription by mutant p53
Sung et al., Int J Radiat Biol 2010 (Lung Neoplasms) : However, when we introduced p53 into H1299 cells, siDcr3 ( siRNA of Dcr3 ) suppressed the radioresistance of H1299 cells by inducing p53 dependent Fas ( Fas receptor, also known as TNFRSF6 ; Tumour necrosis factor receptor super family member 6 ) -mediated apoptosis pathway
Meley et al., Cell death & disease 2010 (Cerebellar Neoplasms...) : The delayed induction was controlled by a p53 dependent transcription step and the production of death receptors ( especially CD95/Fas )
Koster et al., Cell death & disease 2011 (Testicular Neoplasms) : More specifically, our results indicate that p53 dependent induction of Fas membrane expression ( ~threefold ) and enhanced Fas/FasL interactions at the cell surface are important mechanisms of Nutlin-3 induced apoptosis in TC cells
Kuribayashi et al., Cell cycle (Georgetown, Tex.) 2011 : DR5, Fas , Bax, Bad, Puma and Bnip3L were induced by 5-FU and adriamycin ( ADR ) in HCT116 cells in a p53 dependent manner
di Pietro et al., Cell cycle (Georgetown, Tex.) 2012 (Testicular Neoplasms) : Following cisplatin exposure, expression levels of p53 increased , with a subsequent increase in MDM2 and p21 mRNA and protein levels and Fas cell membrane levels
Owen-Schaub et al., Mol Cell Biol 1995 (Adenocarcinoma...) : Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression
Müller et al., J Clin Invest 1997 (Carcinoma, Hepatocellular) : Bleomycin did not increase CD95 in hepatoma cells with mutated p53 ( Huh7 ) or in hepatoma cells which were p53-/- ( Hep3B )
de la Monte et al., J Neurol Sci 1997 (Alzheimer Disease) : Experimentally, apoptosis is preceded by nuclear accumulation of p53 , and increased expression of Fas ( CD95 ) antigen
Sheard et al., Int J Cancer 1997 (Breast Neoplasms) : Interestingly, accumulation of p53 was followed by up-regulation of surface Fas levels between 4 and 8 hr after irradiation ... These findings demonstrate a direct correlation between wild-type-p53 activity and Fas up-regulation after treatment with ionizing radiation, strongly suggesting that post-irradiation Fas up-regulation is dependent on wild-type-p53 activity
Lotem et al., Proc Natl Acad Sci U S A 1998 (Leukemia, Myeloid...) : This suppression of apoptosis by A23187 or TG was associated with suppression of caspase activation but not with suppression of wild-type-p53 induced expression of WAF-1, mdm-2, or FAS
Bennett et al., Science 1998 : In human vascular smooth muscle cells, p53 activation transiently increased surface Fas ( CD95 ) expression by transport from the Golgi complex ... Golgi disruption blocked both p53 induced surface Fas expression and apoptosis ... p53 also induced Fas-FADD binding and transiently sensitized cells to Fas induced apoptosis
Müller et al., J Exp Med 1998 (Neoplasms) : In an attempt to understand how CD95 expression is regulated by p53 , we identified a p53-responsive element within the first intron of the CD95 gene, as well as three putative elements within the promoter