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PTEN — TNF
Text-mined interactions from Literome
Kim et al., J Pharmacol Exp Ther 2004
:
This study shows the signaling pathway by which cilostazol suppresses
tumor necrosis factor-alpha (TNF-alpha) induced the
phosphatase and tensin homolog deleted from chromosome 10 ( PTEN ) phosphorylation and apoptosis via casein kinase 2 ( CK2 ) phosphorylation in the SK-N-SH cells ( neuroblastoma cells )
Vasudevan et al., Mol Cell Biol 2004
:
Importantly,
TNF , a potent inducer of NF-kappa B activity,
suppressed PTEN gene expression in IKK beta ( +/+ ) cells but not in IKK beta ( -/- ) cells, which are deficient in the NF-kappa B activation pathway
Moon et al., Arch Biochem Biophys 2004
:
Furthermore,
PTEN expression strongly decreased MMP-9 promoter activity in
response to
TNF-alpha
Lee et al., Exp Mol Med 2007
(Leukemia) :
TNF-alpha upregulates
PTEN via NF-kappaB signaling pathways in human leukemic cells ... However, here we show the opposite finding that
TNF-alpha upregulates
PTEN via activation of NF-kappaB in human leukemic cells ...
TNF-alpha increased
PTEN expression at HL-60 cells in a time- and dose dependent manner, but the response was abolished by disruption of NF-kappaB with p65 antisense phosphorothioate oligonucleotide or pyrrolidine dithiocarbamate ... We conclude that
TNF-alpha induces upregulation of
PTEN expression through NF-kappaB activation in human leukemic cells
Lo et al., Horm Metab Res 2007
:
Role of tumor suppressor
PTEN in
tumor necrosis factor alpha induced inhibition of insulin signaling in murine skeletal muscle C2C12 cells
Qin et al., Horm Metab Res 2009
(Disease Models, Animal...) :
Quantitative real-time PCR assays showed that CE treatment decreased the mRNA expression of IL-1beta, IL-6 and
TNF-alpha , improved the mRNA expression of IR, IRS1, IRS2, PI3K and Akt1,
inhibited CD36, MTTP, and
PTEN , and enhanced the impaired SREBP-1c expression in TNF-alpha treated enterocytes
Tang et al., Zhonghua Xin Xue Guan Bing Za Zhi 2013
:
TNF-a also significantly
activated the phosphorylation of
PTEN , AKT and FOXO3a ( P < 0.05 )