Gene interactions and pathways from curated databases and text-mining

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PTEN — TNF

Text-mined interactions from Literome

Kim et al., J Pharmacol Exp Ther 2004 : This study shows the signaling pathway by which cilostazol suppresses tumor necrosis factor-alpha (TNF-alpha) induced the phosphatase and tensin homolog deleted from chromosome 10 ( PTEN ) phosphorylation and apoptosis via casein kinase 2 ( CK2 ) phosphorylation in the SK-N-SH cells ( neuroblastoma cells )
Vasudevan et al., Mol Cell Biol 2004 : Importantly, TNF , a potent inducer of NF-kappa B activity, suppressed PTEN gene expression in IKK beta ( +/+ ) cells but not in IKK beta ( -/- ) cells, which are deficient in the NF-kappa B activation pathway
Moon et al., Arch Biochem Biophys 2004 : Furthermore, PTEN expression strongly decreased MMP-9 promoter activity in response to TNF-alpha
Lee et al., Exp Mol Med 2007 (Leukemia) : TNF-alpha upregulates PTEN via NF-kappaB signaling pathways in human leukemic cells ... However, here we show the opposite finding that TNF-alpha upregulates PTEN via activation of NF-kappaB in human leukemic cells ... TNF-alpha increased PTEN expression at HL-60 cells in a time- and dose dependent manner, but the response was abolished by disruption of NF-kappaB with p65 antisense phosphorothioate oligonucleotide or pyrrolidine dithiocarbamate ... We conclude that TNF-alpha induces upregulation of PTEN expression through NF-kappaB activation in human leukemic cells
Lo et al., Horm Metab Res 2007 : Role of tumor suppressor PTEN in tumor necrosis factor alpha induced inhibition of insulin signaling in murine skeletal muscle C2C12 cells
Qin et al., Horm Metab Res 2009 (Disease Models, Animal...) : Quantitative real-time PCR assays showed that CE treatment decreased the mRNA expression of IL-1beta, IL-6 and TNF-alpha , improved the mRNA expression of IR, IRS1, IRS2, PI3K and Akt1, inhibited CD36, MTTP, and PTEN , and enhanced the impaired SREBP-1c expression in TNF-alpha treated enterocytes
Tang et al., Zhonghua Xin Xue Guan Bing Za Zhi 2013 : TNF-a also significantly activated the phosphorylation of PTEN , AKT and FOXO3a ( P < 0.05 )