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PTEN — SP1
Text-mined interactions from Literome
Kang-Park et al., FEBS Lett 2003
(Carcinoma, Hepatocellular...) :
PTEN expression
induced decreased
Sp1 DNA binding by dephosphorylating Sp1 and interfered with transcriptional transactivation of IGF-II by HBx in hepatoma cells
Kou et al., Carcinogenesis 2013
(Neoplasm Invasiveness...) :
Acetylated
Sp1 inhibits
PTEN expression through binding to PTEN core promoter and recruitment of HDAC1 and promotes cancer cell migration and invasion ... In this study, we hypothesized that
Sp1 negatively
regulates PTEN expression ... The results showed that
Sp1 overexpression
inhibited the expression and promoter activity of
PTEN and correspondingly upregulated AKT phosphorylation, whereas Sp1 knockdown upregulated the expression and promoter ability of PTEN and downregulated AKT phosphorylation ... Moreover, a series of deletion and site directed mutations of the PTEN promoter indicated that
Sp1 can
inhibit PTEN promoter activity through a specific Sp1 binding site at the PTEN core promoter in vivo ... Histone deacetylase 1 was necessary for
Sp1 to
inhibit PTEN expression