Gene interactions and pathways from curated databases and text-mining

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CHKA — PTEN

Text-mined interactions from Literome

Puc et al., Cell cycle (Georgetown, Tex.) 2005 : PTEN loss inhibits CHK1 to cause double stranded-DNA breaks in cells
Martin et al., Mol Cancer Ther 2008 : We show that phosphorylation of Chk1 at Ser ( 317 ) but not at Ser ( 345 ) is required for phosphorylation of PTEN at Thr ( 383 ) by CKII, making cell cycle reentry after HU treatment possible