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CSN2 — IFI27
Text-mined interactions from Literome
Sugiyama et al., J Biol Chem 2001
:
Overexpression of Grb2 accelerates
Jab1/CSN5 mediated degradation of
p27 , while Grb3-3 expression suppresses it
Tomoda et al., J Biol Chem 2002
:
Nuclear-cytoplasmic translocation plays an important role because leptomycin B ( LMB ), a chemical inhibitor of CRM1 dependent nuclear export, prevents
p27 degradation
mediated by
Jab1/CSN5 ... A Jab1/CSN5 truncation mutant lacking NES reversed
p27 down-regulation
induced by the full-length
Jab1/CSN5 , indicating that this mutant functions as a dominant negative ( DN-Jab1 )
Pan et al., Cancer Res 2012
(Nasopharyngeal Neoplasms) :
Jab1/CSN5 negatively
regulates p27 and plays a role in the pathogenesis of nasopharyngeal carcinoma ... Aberrant expression of
Jab1/CSN5 , a negative
regulator of the cell-cycle inhibitor
p27 , is correlated with reduced p27 expression and associated with advanced tumor stage and poor prognosis in several human cancers