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LYN — MAPK14

Pathways - manually collected, often from reviews:

• NCI Pathway Database EPO signaling pathway: EPO/EPOR (dimer)/LYN complex (EPO-EPOR-LYN) → p38 alpha (MAPK14) (modification, activates)

Text-mined interactions from Literome

Kawauchi et al., Int J Hematol 2002 (Leukemia, Lymphocytic, Chronic, B-Cell...) : In B-CLL cells, BCR cross linking neither induced activation nor enhanced the activities of Lyn , Syk, p21ras, JNK, p38 MAPK, or Akt kinases, whereas p38 MAPK and Akt were constitutively active
Jiang et al., J Exp Med 1998 : However, BCR mediated p38 MAPK activation was abolished in Lyn/Syk double deficient cells, demonstrating that either Lyn or Syk alone may be sufficient to activate p38 MAPK
Hayashi et al., Nature 1999 : As a result of activation of Lyn , the mitogen activated protein kinase ( MAPK ) signalling pathway is activated, and the expression of brain derived neurotrophic factor (BDNF) messenger RNA is increased in a Lyn-kinase dependent manner