◀ Back to RHOA
RHOA — VEGFA
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Integrins in angiogenesis:
Hsp90 (HSP90AA1)
→
VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3)
(modification, collaborate)
Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
-
NCI Pathway Database Integrins in angiogenesis:
ROCK (ROCK1)
→
VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3)
(modification, collaborate)
Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
-
NCI Pathway Database Integrins in angiogenesis:
alphav/beta3 Integrin complex (ITGAV-ITGB3)
→
VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3)
(modification, collaborate)
Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
-
NCI Pathway Database Integrins in angiogenesis:
VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3)
→
VEGFR2 homodimer/VEGFA homodimer complex (KDR-VEGFA)
(modification, collaborate)
Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
-
NCI Pathway Database Integrins in angiogenesis:
VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3)
→
RhoA (RHOA)
(modification, collaborate)
Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
-
NCI Pathway Database Integrins in angiogenesis:
VEGFR2 homodimer/VEGFA homodimer complex (KDR-VEGFA)
→
RhoA (RHOA)
(modification, collaborate)
Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
RHOA/GDP complex (RHOA)
→
VEGFR2 (dimer)/VEGFA (dimer)/Hsp90/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-HSP90AA1-VTN-ITGAV-ITGB3)
(modification, collaborate)
Le Boeuf et al., J Biol Chem 2004
Evidence: mutant phenotype
-
NCI Pathway Database Integrins in angiogenesis:
VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3)
→
FAK (PTK2)
(modification, activates)
Le Boeuf et al., Mol Biol Cell 2006, Abedi et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
Reactome Reaction:
RHOA
→
VEGFA
(reaction)
Le Boeuf et al., Mol Biol Cell 2006
Text-mined interactions from Literome
van Nieuw Amerongen et al., Arterioscler Thromb Vasc Biol 2003
:
VEGF induced the activation of
RhoA and recruited RhoA to the cell membrane of human ECs
Le Boeuf et al., J Biol Chem 2004
:
Moreover, geldanamycin inhibited the
VEGF induced activation of the small GTPase
RhoA , which resulted in an inhibition of phosphorylation of FAK on site Tyr ( 407 )
SanĂger et al., J Cell Biochem 2006
:
c-Jun kinase mediates expression of
VEGF induced at transcriptional level by Rac1 and Cdc42Hs but not by
RhoA
Singleton et al., Microvasc Res 2006
(Neoplasms...) :
Furthermore, MS, DAMGO and
VEGF induced
RhoA activation which was inhibited by MNTX or VEGF receptor tyrosine kinase inhibition
Nacak et al., Circ Res 2007
:
The depletion of KLEIP in endothelial cells blunted the
VEGF induced activation of the monomeric GTPase
RhoA but did not alter the VEGF stimulated activation of extracellular signal regulated kinase 1/2
Ispanovic et al., Am J Physiol Cell Physiol 2008
:
VEGF stimulation also
induced activation of Cdc42 while inhibiting
RhoA activity
Bryan et al., FASEB J 2010
:
We demonstrate that
vascular endothelial growth factor-A ( VEGF ) rapidly
induces RhoA activation in endothelial cells ( ECs )
Zhu et al., Cell cycle (Georgetown, Tex.) 2011
(MAP Kinase Signaling System...) :
Biochemical analysis suggests that hMSC-CM induces the expression of
VEGF of tumor cells as well as the
activation of
RhoA-GTPase and ERK1/2
Ma et al., Nan Fang Yi Ke Da Xue Xue Bao 2012
(Breast Neoplasms) :
[
Role of
RhoA in hypoxia induced breast cancer cell
VEGF secretion and proliferation, migration and tube formation of HUVECs ] ... To explore the
role of
RhoA in regulating
vascular endothelial growth factor ( VEGF ) secretion level in breast cancer cells and in the proliferation, migration and tube formation of human umbilical vascular endothelial cells ( HUVECs ) under hypoxia ... Under hypoxic condition, RhoA activation promoted
VEGF secretion in MCF-7 cells, and
RhoA knockdown
inhibited VEGF secretion
Wu et al., American journal of physiology. Renal physiology 2013
:
VEGF induced
RhoA activation was prevented by disrupting caveolae with cholesterol depletion and rescued by cholesterol repletion ... Overexpression of nonphosphorylatable caveolin-1 Y14A prevented
VEGF induced
RhoA activation and fibronectin upregulation