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EPHB2 — TP53

Text-mined interactions from Literome

Persons et al., J Biol Chem 2000 : In the present study, we examined the potential role of ERK1/2 activation in regulation of the p53 response to cisplatin ... In the ovarian carcinoma cell line A2780, inhibition of ERK1/2 activation with the mitogen activated protein kinase/ERK kinase 1 ( MEK1 ) inhibitor PD98059 resulted in decreased p53 protein half-life and diminished accumulation of p53 protein during exposure to cisplatin
She et al., Cancer Res 2001 : Stable expression of a dominant negative mutant of ERK2 or p38 kinase or their respective inhibitor, PD98059 or SB202190, repressed the phosphorylation of p53 at serine 15
Sablina et al., Oncogene 2001 : p53 activation in response to microtubule disruption is mediated by integrin-Erk signaling
Agarwal et al., Oncogene 2001 (Fibrosarcoma...) : Overexpression of ERK2 in AP14 cells restored both MAP kinase activity and p53 expression, and incubation of the mutant cells with the phosphatase inhibitor orthovanadate resulted in strong coordinate elevation of MAP kinase activity and p53 expression
Park et al., Brain Res Mol Brain Res 2001 (Neuroblastoma) : Bcl-2 blocks cisplatin induced apoptosis by suppression of ERK mediated p53 accumulation in B104 cells ... These results suggest that ERK mediates cisplatin induced p53 activation to trigger apoptosis in B104 cells
DeHaan et al., Cancer Chemother Pharmacol 2001 : Furthermore, we have demonstrated that cisplatin induced ERK activation is required for optimal p53 protein accumulation following cisplatin induced DNA damage
Sipeki et al., Cell Signal 2002 (MAP Kinase Signaling System) : This increase of p53 levels was probably due to the transient stabilisation of p53 and did not require the activation of Erk1/Erk2
Lin et al., Cancer Res 2002 (Breast Neoplasms) : Expression of wt p53 did not cause a reduction in the phosphorylation of three unrelated protein kinases in other signal transduction pathways, AKT, extracellular signal regulated kinase ( ERK ) 1, and ERK2 or a reduction of phosphorylation of epidermal growth factor receptor
She et al., Oncogene 2002 : In contrast, dominant negative ERK2 or the MEK1 inhibitor, PD98059, had no effect on p53 phosphorylation at serine 20
Dios et al., J Med Chem 2002 : We found that compound 8 binding to MIF active site resulted in the inhibition of MIF bioactivity in three established bioassays : ERK-1/2 MAP kinase activation , p53 dependent apoptosis, and proliferation of serum starved cells
Lee et al., Cell Growth Differ 2002 : Moreover, p53 and p21 ( Waf ) induction by radiation were higher in PKCdelta overexpressed cells than control cells, and PKCdelta mediated apoptosis was reduced , when radiation induced ERK1/2 activity was inhibited by PD98059
Woessmann et al., Cancer Chemother Pharmacol 2002 (Bone Neoplasms...) : Activation of ERK is required for accumulation and phosphorylation of p53 following cisplatin treatment
Ho et al., Eur J Clin Invest 2003 (Mouth Neoplasms) : Inhibited the activation of p42/p44 mitogen activated protein kinase ( MAPK ) by PD98059, a specific inhibitor of extracellular regulatory kinase (ERK) , significantly decreased cell viability and enhanced the expression of p53 induced by ASA
Nair et al., J Biol Chem 2004 (MAP Kinase Signaling System) : Whereas the proportion of cells activating ERK versus p53 at 1 h depended on H ( 2 ) O ( 2 ) concentration, individual cells showed exclusively either phospho-p53 formation or activation of ERK and egr1 induction ... Repressing p53 with pifithrin-alpha or small interfering RNA increased ERK phosphorylation by H ( 2 ) O ( 2 ), indicating that p53 dependent suppression of ERK activity may contribute to the bi-stable single cell responses observed
Marchetti et al., Cell Death Differ 2004 : Likewise, DNA damage induced cell cycle arrest correlates with p53 dependent ERK2 downregulation and caspase activation
Ko et al., Exp Cell Res 2004 (Adenocarcinoma...) : Decreasing phospho-ERK with the pharmacological inhibitors, PD98059 and U0126, markedly suppresses hyperoxia stimulated phospho-p53 ( Ser15 ), p53, and p21 ( CIP1 ), and also restores the hyperoxia reduced kinase activities of cyclin D1/E1-Cdks
Bao et al., J Cell Biol 2004 (MAP Kinase Signaling System...) : Surprisingly, MEK1 and ERK1/2 activities were restored in integrin alphav negative melanoma cells by suppression of p53 , whereas concomitant block of MEK1 induced apoptosis
Ostrakhovitch et al., J Cell Biochem 2005 (Breast Neoplasms) : Recent studies have shown that MEK/ERK mediated signals play a major role in regulation of activity of p53 tumor suppressor protein ... Mutation or suppression of p53 in MDA-MB231 and MCF7-E6 cells, respectively, resulted in a strong ERK phosphorylation in the presence of metals
Wu et al., Chin Med J (Engl) 2005 : Phosphorylation of ERK resulted in up-regulation of p53 expression, which was blocked by mitogen activated protein kinase ( MEK ), inhibitor PD 98059
Andrysík et al., Toxicol Appl Pharmacol 2006 : Pifithrin-alpha, inhibitor of p53 transcriptional activity, prevented induction of apoptosis and activation of ERK1/2 and p38
McCubrey et al., Biochim Biophys Acta 2007 (Cell Transformation, Neoplastic...) : Raf/MEK/ERK may promote cell cycle arrest in prostate cells and this may be regulated by p53 as restoration of wild-type p53 in p53 deficient prostate cancer cells results in their enhanced sensitivity to chemotherapeutic drugs and increased expression of Raf/MEK/ERK pathway
Singh et al., FEBS Lett 2007 (Carcinoma...) : p53 regulates ERK activation in carboplatin induced apoptosis in cervical carcinoma : a novel target of p53 in apoptosis
Kim et al., Mol Cancer Res 2007 : ERK1/2 or Akt was not responsible for p53 repression due to G alpha(12) deficiency
Park et al., Int J Mol Med 2008 (Cell Transformation, Neoplastic) : Studies on the regulation of apoptosis showed that apicidin induces the up-regulation of p53 and the downstream activation of ERK in MCF10A-ras cells
Bove et al., J Biol Chem 2008 (Inflammation) : Collectively, our results demonstrate that inflammatory levels of NO inhibit epithelial cell migration, because of suppression of ERK1/2 signaling, and activation of HIF-1alpha and p53 , with potential consequences for epithelial repair and remodeling during airway inflammation
Lee et al., J Neurochem 2009 (Neuroblastoma) : Furthermore, inhibition of ERK reduced ONE induced phosphorylation of p53 , a key modulator of the cellular stress response, and the proteolytic cleavage of poly ( ADP-ribose ) polymerase ( PARP ), a hallmark of apoptosis
Cheng et al., Arch Biochem Biophys 2009 (Fibrosarcoma) : In addition, we discovered that interruption of p53 activation decreased oridonin induced apoptosis, and blocking ERK by specific inhibitors or siRNA suppressed oridonin induced p53 activation
Al-Anati et al., Chem Biol Interact 2009 (Carcinoma, Hepatocellular...) : We have previously shown that TCDD attenuates p53 response by phosphorylating its regulator Mdm2 at Ser166, and that Erk can mediate this effect in hepatocytes
Smirnova et al., Cell Immunol 2010 : Lastly, etoposide treatment of immature thymocytes induced both p53 and ERK1/2 activation, but ERK1/2 activity did not affect the phosphorylation and stabilization of p53
Wang et al., Pharmazie 2010 (Brain Neoplasms...) : It suppressed drug related Cdk1 activity with a less elevation of regulator proteins such as cyclin B1, Cdk7 and reduced caspase activation and PARP cleavage compared to the efficiency observed in normoxic condition, which were significantly relative with hypoxia-driven inhibition of p53 and p-ERK1/2 activation
Wang et al., Oncol Rep 2010 (Carcinoma, Hepatocellular...) : Immunoblot analysis demonstrated that oridonin treatment increased expression levels of p-JNK, p-p38, p-p53 and p21, elevated the level of cyclin B1/p-Cdc2 ( Tyr15 ) complex, and inhibited the expression of p-ERK
Gupta et al., J Biol Chem 2011 (Adenocarcinoma...) : Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK dependent up-regulation of death receptors, p53 , and Bax ... Overall, our results indicate that nimbolide can sensitize colon cancer cells to TRAIL induced apoptosis through three distinct mechanisms : reactive oxygen species- and ERK mediated up-regulation of DR5 and DR4, down-regulation of cell survival proteins, and up-regulation of p53 and Bax
Lin et al., Cell Death Differ 2011 (Myocardial Reperfusion Injury) : Intracellular zinc release activated ERK dependent GSK-3ß-p53 and Noxa-Mcl-1 signaling are both involved in cardiac ischemic-reperfusion injury
Wu et al., Biochem Pharmacol 2011 : In addition, knockdown of NAPA induced the activation of the MAPK kinases ERK, JNK and p38, but only inhibition of ERK reduced synoviolin ubiquitination and p53 accumulation
Park et al., Mol Carcinog 2012 (Colonic Neoplasms...) : HFD feeding increased tumor tissue levels of Ki67, cyclin A, cyclin D1, CDK2, Bcl-xL, and Bcl-2 ; reduced p53 levels and TUNEL positive apoptotic cells ; increased the levels of CD45, CD68, CD31, VEGF, P-VEGF receptor-2, iNOS, and COX-2 as well as hemoglobin content ; and increased the levels of HIF-1a, P-STAT3-Y705, P-STAT3-S727, P-I?B-a, P-p65, p65, P-c-Jun, P-Akt, P-ERK1/2 , P-p38, and P-SAPK/JNK
Lee et al., Toxicol In Vitro 2011 (Mouth Neoplasms) : These results provide the first evidence that sappanchalcone suppresses oral cancer cell growth and induces apoptosis through the activation of p53 dependent mitochondrial, p38, ERK , JNK, and NF-?B signaling
Liu et al., J Pharmacol Sci 2012 (Lung Neoplasms) : Interruption of ERK and p53 activities decreased SU11274 induced autophagy, and blocking of ERK by the specific inhibitor PD98059 suppressed SU11274 induced p53 activation ... Moreover, ERK activation upregulated Beclin-1 expression through induction of Bcl-2 phosphorylation, but p53 did not induce Bcl-2 phosphorylation
Heo et al., Mol Biol Rep 2012 : ERK inhibitor prevented p53 phosphorylation, indicating that phosphorylations of p53 and p-ERK are interdependent each other
Lv et al., Marine drugs 2013 (Carcinoma...) : Moreover, asperolide A significantly activated MAP kinases ( ERK1/2, JNK and p38 MAP kinase ) by phosphorylation, and only the inhibition of ERK activation by PD98059 reversed downregulation of G2/M regulatory proteins CDC2, and suppressed upregulation of p21 and p-p53 levels
Sinha et al., Cell death & disease 2013 (Brain Neoplasms...) : Transfection with TIGAR mutant ( i ) decreased apoptosis and ?H2AX foci formation ( ii ) decreased p53 ( iii ) elevated ROS and ( iv ) increased Akt/Erk activation in cells cotreated with NCS and TNFa
Lee et al., Neoplasia (New York, N.Y.) 2013 : To address this, we evaluated the effects of p53 on the extracellular signal regulated kinase ( ERK ) activation and found that p53 could suppress ERK activation through de novo synthesis ... Through several molecular biologic analyses, we found that RKIP, an inhibitor of Raf kinase, is responsible for p53 mediated ERK suppression and senescence