Cooper et al., PloS one 2011
(Inflammation) :
Through the use of PAR-1 and PAR-2 neutralizing antibodies, it was determined that PAR-1 is essential for GrK induced IL-6, IL-8 and MCP-1 release
Packiriswamy et al., Cell Immunol 2012
(Systemic Inflammatory Response Syndrome) :
However, GRK5 regulates IL-5 and MCP-1 in a MyD88 dependent but TNFa in a TRIF dependent manner