◀ Back to IL6

IL1RN — IL6

Text-mined interactions from Literome

Mühlberg et al., J Clin Endocrinol Metab 2000 (Graves Disease) : Recent data have indicated that orbital fibroblasts ( OF ) can be stimulated to produce marked quantities of interleukin-1 receptor antagonist ( IL-1RA ), a powerful inhibitor of the proinflammatory activities of interleukin-1 in the orbital tissues in Graves ' ophthalmopathy ( GO )
Axtelle et al., J Endotoxin Res 2001 (Sepsis) : IC14 inhibited the release of TNF-alpha, IL-6 , and IL-10 and delayed the release of sTNFR ( I ) and IL-1ra
Bishop et al., Int J Sport Nutr Exerc Metab 2001 : Therefore, the present study investigated the influence of pre-exercise CHO status on plasma interleukin (IL)-6 , IL-10, and IL-1 receptor antagonist (IL-1ra) responses to prolonged cycling
Steensberg et al., Am J Physiol Endocrinol Metab 2003 : IL-6 enhances plasma IL-1ra , IL-10, and cortisol in humans ... In conclusion, this study demonstrates that physiological concentrations of IL-6 induce an anti-inflammatory rather than an inflammatory response in humans and that IL-6 , independently of TNF-alpha, enhances the levels not only of IL-1ra but also of IL-10
Garat et al., Cytokine 2003 : The goal of this study was to determine the role of icIL-1Ra1 in regulation of cytokine induced IL-6 and IL-8 production in Caco-2 intestinal epithelial cells
Bertini et al., Cytokine 1992 : Recombinant icIL-1ra inhibited the IL-1 induced production of IL-6 , IL-8 and monocyte chemotactic protein by human endothelial cells ( HEC )
Zoja et al., J Am Soc Nephrol 1992 : Recombinant interleukin-1 receptor antagonist blocked the interleukin-1 mRNA as well as interleukin-6 and interleukin-8 mRNA accumulation induced by interleukin-1 beta
Johnson et al., Neuroscience 2004 : IL-1ra had no effect on basal proinflammatory cytokines, but completely blocked the stress induced enhancement in central and pituitary IL-1beta and plasma IL-6 release following LPS challenge
Cominelli et al., Gastroenterology 1992 (Colitis) : Recombinant interleukin-1 receptor antagonist blocks the proinflammatory activity of endogenous interleukin-1 in rabbit immune colitis
Kawano et al., Fertil Steril 2004 : The effects of IL-1alpha, IL-1 receptor antagonist (IL-1RA) , C2-ceramide, and C6-ceramide on the production of IL-6 , IL-8, and M-CSF by ESC
Hoffman et al., Lancet 2004 (Acute Disease...) : IL-1Ra administered before cold challenge blocked symptoms and increases in white-blood-cell counts and serum interleukin 6
Molnar et al., Eur Cytokine Netw 2004 (Liver Failure...) : Incubation of HepG2 cells with interleukin-1beta (IL-1beta) caused an increase in IL-1Ra levels, while interleukin-6 (IL-6) had no effect on IL-1Ra synthesis
Kaminska et al., Tumour Biol 2005 (Colorectal Neoplasms) : The levels of circulating interleukin (IL)-6, IL-8, macrophage colony stimulating factor ( M-CSF ) and interleukin 1 receptor antagonist ( IL-1ra ) significantly increased with the clinical stage of CRC, and the levels of IL-6 , soluble tumor necrosis factor ( sTNF ) receptor type I ( RI ), soluble interleukin 2 receptor alpha and TNFalpha with tumor grade, while IL-6, IL-8, M-CSF, IL-1ra and sTNF RI levels significantly rose with bowel wall invasion
Inoue et al., Pediatr Surg Int 2007 : In neonates, the perioperative serum level of IL-1ra was significantly raised, and the postoperative IL-6 response was well controlled
Mengozzi et al., Lymphokine Cytokine Res 1991 : We tested the effect of IL-1ra on IL-1 induced lethality in adrenalectomized mice, hypoglycemia, and induction of serum corticosterone and interleukin 6 ... IL-1ra at 20 micrograms/mouse completely blocked induction of IL-6 and markedly inhibited hypoglycemia and increase in serum corticosterone induced by 0.1 micrograms of IL-1
Bastian et al., Eur Surg Res 2008 : The acute sterile inflammation after major orthopaedic surgery is principally characterized by significantly increased local and systemic levels of IL-6 and significantly increased local levels of IL-8 and IL-1Ra
Lee et al., J Nutr 2009 : 9E,11E-CLA induced IL-1Ra in a dose- and time dependent manner, whereas it decreased lipopolysaccharide (LPS) induced IL-1alpha, IL-1beta, and IL-6 mRNA levels and protein levels
Triozzi et al., Invest Ophthalmol Vis Sci 2011 (Melanoma...) : In vitro, IL-1, and IL-1ra did not affect the proliferation of the uveal melanoma cells or their production of IL-1, IL-6 , transforming growth factor ( TGF ) ß, or VEGF
Liu et al., Brain Behav Immun 2012 (Breast Neoplasms...) : Compared to baseline, more fatigue was reported, levels of IL-6 increased and IL-1RA decreased during chemotherapy
Akash et al., Pharm Res 2012 : When compared directly, IL-1Ra loaded PF127 gel exhibited prolonged in vitro and in vivo release, greater efficacy to induce hypoglycemia and inhibited IL-1ß stimulated production of IL-6 as compared to IL-1Ra aq. solution
Burger et al., J Clin Invest 1995 : The inhibitory activity of human interleukin-1 receptor antagonist is enhanced by type II interleukin-1 soluble receptor and hindered by type I interleukin-1 soluble receptor
Louie et al., J Acquir Immune Defic Syndr Hum Retrovirol 1995 (Acquired Immunodeficiency Syndrome...) : As expected, IL-1ra also blocks IL-1 mediated upregulation of IL-6 and bFGF, both of which are autocrine growth factors for KS
Everaerdt et al., J Immunol 1994 (Neoplasms, Experimental) : However, the induction of high levels of circulating IL-6 by murine TNF was not affected, although IL-1ra almost completely blocked the induction of IL-6 by exogenously administered IL-1
Schotanus et al., Endocrinology 1993 : Human recombinant interleukin-1 receptor antagonist prevents adrenocorticotropin, but not interleukin-6 responses to bacterial endotoxin in rats ... At a dose of 1 mg/kg, IL-1RA inhibited ACTH and IL-6 responses to rIL-1 beta ( 2.5 micrograms/kg, ip ) by 75 % and 90 %, respectively
Tilg et al., Blood 1994 (Neoplasms) : Peripheral blood mononuclear cells ( PBMC ) exposed to IL-6 produced only small amounts ( 1.56 +/- 0.3 ng/mL ) of IL-1Ra , even in the presence of exogenous soluble IL-6 receptor ( gp80 ) ... Our findings also suggest that tissue macrophages may be an important source of IL-6 induced IL-1Ra
Araki et al., Int J Cancer 1994 (Melanoma) : Furthermore, constitutive production of IL-6 in resistant cells was inhibited by IL-1Ra
Romero et al., Neuroendocrinology 1993 : To test this hypothesis, the effects of IL-1 receptor antagonist (IL-1Ra) on LPS and IL-1 induced IL-6 secretion were tested in a mixed brain cell culture from 17-day fetal rat, after 12-14 days in culture
Strassmann et al., J Immunol 1993 (Cachexia...) : Both IL-1R antagonist (IL-1RA) and the mAb 35F5 directed against IL-1R type I, prevented binding of radioactive IL-1, and inhibited IL-1 induced IL-6 synthesis by the C-26 cell line
Lu et al., Stem Cells 1995 (Multiple Myeloma) : An interleukin 1 receptor antagonist blocks the IL-1 induced IL-6 paracrine production through a prostaglandin E2-related mechanism in multiple myeloma ... An IL-1 receptor antagonist (IL-1RA) also significantly inhibits PGE2, IL-6 production and myeloma cell growth
De Benedetti et al., Clin Exp Rheumatol 1995 : The increase in IL-1Ra levels does not appear to reflect an increase in IL-1 production, but may rather be induced by IL-6
Schuler et al., J Interferon Cytokine Res 1996 (Acute-Phase Reaction...) : Furthermore, the anti-inflammatory molecules sTNF-R p55 and p75 were induced by IL-6 , whereas serum levels of IL-1RA remained unchanged
Miller et al., Br J Pharmacol 1997 (Fever...) : 2. To investigate the effect of IL-1ra on fever and the induction of local and circulating cytokines ( IL-1 and IL-6 ), separate experiments were performed in which groups of animals were killed 1.5, 3 or 5 h after LPS injection
Fantuzzi et al., Am J Physiol 1997 (Inflammation) : In IL-1 beta +/+ mice, IL-1ra inhibited production of IL-6 after zymosan, without affecting TNF-alpha synthesis
Takemura et al., J Rheumatol 1998 (Scleroderma, Systemic) : However, IL-1 receptor antagonist (IL-1ra) , when added in the medium, significantly inhibited the PDGF induced IL-6 production by SSc fibroblasts
Costes et al., Br J Haematol 1998 (Multiple Myeloma) : In fact, an IL-1 receptor antagonist (IL-1RA) blocked PGE2 synthesis and IL-6 production by 80 % ; this blockage could be reversed by adding synthetic PGE2