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AKT3 — GDNF

Text-mined interactions from Literome

Focke et al., J Neurobiol 2001 : We found that GDNF stimulates the phosphorylation of both the PI 3-kinase downstream substrate Akt and the MAP kinase substrate ERK in cultures of immunoaffinity purified embryonic avian enteric crest derived cells ... The selective PI 3-kinase inhibitor LY-294002 blocked GDNF stimulated Akt phosphorylation in purified crest cells, and reduced proliferation in cultures of dissociated quail gut
Jin et al., Brain Res 2002 : Activation of cell-survival signal Akt by GDNF in normal rat brain
Steinkamp et al., Gastroenterology 2003 : GDNF induced activation of Akt ( protein kinase B [PKB ] ) and mitogen activated protein kinase ( MAPK ) in the colonic epithelial cell lines HT-29 and SW480 was studied ... GDNF potently activated MAPK and Akt ( PKB ) in colonic epithelial cells
Hirata et al., Brain Res 2003 (Brain Neoplasms...) : GDNF induces the phosphorylation of Akt and p70S6 kinase (p70S6K) in SH-SY5Y cells in which Ret protein expression is relatively low
Maeda et al., Biochem Biophys Res Commun 2004 : Expression of Gab1 PI3K-m in SK-N-MC human primitive neuroectodermal tumor cells expressing wild-type RET markedly impaired Akt phosphorylation, Rac1 activation, and lamellipodia formation that were induced by GDNF whereas expression of Gab1 SHP2-m partially impaired Erk activation
Coulpier et al., Mol Cell Neurosci 2004 : Retrograde signaling was associated with retrograde transport of radiolabeled GDNF and GFR alpha 1, as well as activation of RET and AKT , but not of ERK1/2, in cell bodies
Srinivasan et al., Mol Cell Neurosci 2005 (MAP Kinase Signaling System) : Specifically, GDNF induces phosphorylation of Akt and loss of the Akt substrates FOXO1 and FOXO3a from the nucleus of ENS precursors
Wang et al., Acta Pharmacol Sin 2007 (MAP Kinase Signaling System) : Meanwhile, the stimulation of cultured cells with GDNF increased the phosphorylation of Akt , which is a downstream effector of PI3-K/Akt
Cañibano et al., EMBO J 2007 (Neoplasms) : In the presence of GDNF , Akt is activated, and the Pit-1 overexpression and resulting apoptosis are blocked
Oatley et al., J Biol Chem 2007 : Next, GDNF was shown to activate both Akt and Src family kinase (SFK) signaling in SSCs, and culture of SSCs with inhibitors to Akt or SFKs followed by transplantation analysis showed significant impairment of SSC maintenance in vitro
Narita et al., Oncogene 2009 (Melanoma...) : GDNF stimulation of RETp cell lines enhanced phosphorylation of extracellular signal regulated kinase ( ERK ) and Akt of the RET-RAS-RAF-ERK and RET-phosphatidylinositol 3-kinase (PI3K)-Akt pathways, respectively
Zhang et al., J Pathol 2010 (Colitis...) : Our results showed that GDNF resulted in a significant reduction in enhanced permeability, inhibited MPO activity, IL-1beta and TNF-alpha expression, and increased ZO-1 and Akt expression
Shukla et al., Neurotoxicology 2013 : Sal toxicity coincided with reduced pAkt level and its downstream effectors : pCREB, pGSK-3ß, Bcl-2 and neurotrophins GDNF , BDNF suggesting repressed PI3K/Akt signaling
Yuan et al., Chin Med J (Engl) 2013 (Stroke) : Grafting GDNF/NSCs enhances neurogenesis and activates Akt and Erk1/2 signaling, that may provide the potential for GDNF/NSCs in stroke treatment