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MAPK10 — PEBP1
Text-mined interactions from Literome
Trakul et al., J Biol Chem 2005
(MAP Kinase Signaling System) :
Here, we show that
RKIP inhibits
MAPK by regulating Raf-1 activation ; specifically, RKIP acts subsequent to Raf-1 membrane recruitment, prevents association of Raf-1 and p21 activated kinase (PAK), and blocks phosphorylation of the Raf-1 kinase domain by PAK and Src family kinases ... Because c-Raf-1 and B-Raf are both required for maximal MAPK stimulation by epidermal growth factor in neuronal and epithelial cell lines, we determined whether
RKIP significantly
affects MAPK signaling
Zeng et al., Expert Opin Ther Targets 2008
(Cell Transformation, Neoplastic...) :
In mammals,
RKIP regulates activation of
MAPK , NF-kappaB and G protein coupled receptors ( GPCRs )
Ma et al., Liver Int 2009
:
Raf kinase inhibitor protein inhibits
ERK/MAPK signalling and this inhibition impedes HSC proliferation
Eves et al., Methods Mol Biol 2010
:
As demonstrated by immunofluorescence at kinetochores, depletion of
Raf Kinase Inhibitory Protein (RKIP) , an inhibitor of Raf/MEK/ERK signaling,
causes an increase in
MAPK activity that inhibits Aurora B kinase activity
Antoun et al., J Neurosci 2012
(MAP Kinase Signaling System) :
Collectively, our data reveal an important
role of
RKIP in the regulation of
MAPK/ERK signaling in the SCN and photic entrainment of the SCN clock
Zeng et al., Cell Signal 2013
(MAP Kinase Signaling System) :
Here, we demonstrate that
Raf kinase inhibitory protein (RKIP) regulates the activation of
MAPK when B-Raf signaling is defective