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PDB1 — PTGS2

Text-mined interactions from Literome

Pham et al., J Cell Biochem 2006 : Expression of a dominant negative CREB ( S133A ) blocked PDB/TG dependent induction of both COX-2 and mPGES-1 promoters ... Decreased CREB expression by siRNA blocked PDB/TG dependent expression of COX-2 and mPGES-1 mRNA ... These findings demonstrate a coordinated induction of COX-2 and mPGES-1 by PDB/TG that proceeds through PKC/ERK and Ca2+ signaling cascades, resulting in increased PGE2 production
Nam et al., Prostaglandins 1996 : PDB increased COX-2 mRNA levels by 2 hours, and COX activity tripled after 12 hr exposure to PDB