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CGA — PTGS2

Text-mined interactions from Literome

Connolly et al., Endocrinology 2007 : Immunocytochemical and immunoblotting analyses confirmed that both intracellular and secreted levels of CGA were elevated in response to Cox-2 induction ... Levels of neuron-specific enolase were similar in the two cell lines, suggesting that the effect of Cox-2 on CGA expression was specific and not due to a global enhancement of neuroendocrine marker expression/differentiation ... Cox-2 dependent CGA up-regulation was associated with significantly increased chromaffin granule number and intracellular and secreted levels of dopamine
Shan et al., Int Immunopharmacol 2009 : In conclusion, CGA suppresses LPS induced COX-2 expression via attenuating the activation of NF-kappaB and JNK/AP-1 signaling pathways suggesting that CGA, the polyphenol compound in our food, could exert anti-inflammatory effects through inhibiting PGE ( 2 ) production