Gene interactions and pathways from curated databases and text-mining

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NOS2 — SPHK1

Text-mined interactions from Literome

Vann et al., J Biol Chem 2002 (Glioma) : In contrast, enforced expression of sphingosine kinase had no effect on iNOS expression or NO formation
Kacimi et al., J Mol Cell Cardiol 2007 (Anoxia) : To determine whether SphK regulates cell proliferation and the proinflammatory protein inducible nitric oxide synthase (iNOS) , we exposed cultured cardiac fibroblasts to the cytokine interleukin-1beta (IL-1beta) and/or hypoxia
Nayak et al., Neuroscience 2010 (Encephalitis...) : Suppression of SphK1 by its inhibitor, N, N Dimethylsphingosine ( DMS ), or siRNA resulted in decreased mRNA expression of TNF-alpha, IL-1beta, and iNOS and release of TNF-alpha and nitric oxide ( NO ) in LPS activated microglia